protein

Recombinant Human S100A16

CR33

10 ug;50 ug;500 ug;1 mg

Recombinant Protein

Recombinant Human S100A16

Recombinant Proteins

CR33-10ug

10 ug;50 ug;500 ug;1 mg

Q96FQ6

S100A16 is a member of S100 protein superfamily that carries calcium-binding EF-handmotifs. S100 proteins are cell-and tissue-specific and are involved in many intra-and extracellular processes hrough interacting with specific target proteins. S100A16 expression was found to be astrocyte-specific. The S100A16 protein was found to accumulate within nucleoli and to translocate to the cytoplasm in response to Ca(2+) stimulation. The homodimeric structure of human S100A16 in the apo state has been obtained both in the solid state and insolution, resulting in good agreement between the structures with the exception of two loop regions. The homodimeric solution structure of human S100A16 was also calculated in the calcium(II)-bound form. Immunoprecipitation analysis revealed that S100A16 could physically interact with tumor suppress or protein p53, also a known inhibitor of adipogenesis. Overexpression or RNA interference-initiated reduction of S100A16 led to the inhibition or activation of the expression of p53-responsivegenes, respectively. S100A16 protein is a novel adipogenesis-promoting factor.

E. coli

Ambient

Lyophilized from a 0.2 μm filtered solution of 20mM Tris, 500mM NaCl, pH8.0.

Protein S100-A16; Aging-associated gene 13 protein; Protein S100-F; S100 calcium-binding protein A16; S100A16; S100F; AAG13