protein

Recombinant Human Tumor Necrosis Factor Receptor II/TNFRSF1B/CD120b (C-Fc)

CP11

10 ug;50 ug;500 ug;1 mg

Recombinant Human Tumor Necrosis Factor Receptor II/TNFRSF1B/CD120b (C-Fc)

protein

P20333

10 ug;50 ug;500 ug;1 mg

95

CP11-10ug

10ug;50ug;500ug;1mg

Recombinant Human Tumor Necrosis Factor Receptor II is produced by our expression system and the target gene encoding Leu23-Asp257 is expressed with a Fc tag at the C-terminus.

Human Cells

Tumor necrosis factor receptor superfamily member 1B (TNFRSF1B) is a member of the tumor necrosis factor receptor superfamily. Human TNF RII contains four cysteinerich repeats in its ECD, which shares 58% and 56% amino acid sequence identity with the mouse and rat orthologs, respectively.TNF RII is expressed predominantly on cells of the hematopoietic lineage, such as T and natural killer cells, as well as on endothelial cells, microglia, astrocytes,neurons, oligodendrocytes, cardiac myocytes, thymocytes, and mesenchymal stem cells.TNF RII binds to the membranebound forms of TNF and Lymphotoxin/TNFbeta;soluble TNF is thought to signal predominately through TNF RI.Soluble TNF RII is believed to inhibit TNF biological activity by binding TNF thereby preventing it from activating membrane TNF receptors.

Less than 0.1 ng/ug (1 EU/ug)

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4

Ambient

Tumor necrosis factor receptor superfamily member 1B, TNFRSF1B, Tumor necrosis factor receptor 2, TNF-R2, TNF-RII, Tumor necrosis factor receptor type II, p75, p80 TNF-alpha receptor, CD120b