protein

Recombinant Mouse IL-1 Receptor-Like 1/IL-1RL1/IL-1 R4 (C-Fc)

CK95

10 ug;50 ug;500 ug;1 mg

Recombinant Protein

Recombinant Mouse IL-1 Receptor-Like 1/IL-1RL1/IL-1 R4 (C-Fc)

Recombinant Proteins

CK95-10ug

10 ug;50 ug;500 ug;1 mg

P14719-2

ST2, also called IL-1 R4, is an Interleukin-1 receptor family glycoprotein that plays a role in Th2 immune responses. ST2 is expressed on the surface of mast cells, activated Th2 cells, macrophages, and cardiac myocytes. This receptor is very similar to the IL-1 receptor type I and the IL-18 receptor α chain in that ST2 also has three extracellular Ig domains and an intracellular Toll domain. ST2 binds IL-33, enhances inflammatory cytokines by activating nuclear factor-κB (NF-κB) and mitogen activated protein (MAP) kinases. ST2 exists as either a membrane bound form (ST2L) or as a soluble form (sST2). ST2L acts as a transmembrane signalling receptor for IL-33 by mediating the effect of IL-33 on the inflammatory process, while sST2 can suppress IL-33 activity.

Human Cells

Ambient

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Interleukin-1 receptor-like 1, Lymphocyte antigen 84, Protein ST2, Protein T1, Il1rl1, DER4, Fit-1, IL-1 R4, IL-1RL1, IL-33R, Ly84, ST2L, ST2V, suppression of tumorigenicity 2