protein

Recombinant Human Thymic Stromal Lymphopoietin/TSLP

CK16

10 ug;50 ug;500 ug;1 mg

Recombinant Human Thymic Stromal Lymphopoietin/TSLP

protein

Q969D9

10 ug;50 ug;500 ug;1 mg

150

CK16-10ug

10ug;50ug;500ug;1mg

Recombinant Human Thymic stromal lymphopoietin is produced by our E.coli expression system and the target gene encoding Tyr29-Gln159 is expressed.

E. coli

Thymic stromal lymphopoietin (TSLP) is a novel member of the hemopoietic cytokine family that promotes the development of B cells and shares overlapping activity with IL-7. The human TSLP protein comprises a 28 amino acids (aa) signal sequence and 131 aa mature region. Human TSLP has two isoforms lfTSLP (159 aa) and sfTSLP (63 aa) produced by alternative splicing . lfTSLP (159aa) is expressed in a number of tissues including heart, liver and prostate, and sfTSLP (63aa) is predominantly expressed in keratinocytes of oral mucosa, skin and in salivary glands. In aa sequence level, Human TSLP displays about 43% identity with mouse TSLP. Thymic stromal lymphopoietin (TSLP) is a cytokine that functions mainly on myeloid cells; it induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells . TSLP has proliferative effects on the myeloid cell line and may initiate asthma or atopic dermatitis responses by directly activating mast cells . TSLP signals cells via the interleukin-7 receptor- chain (IL-7R), shared with IL-7, together with the TSLP receptor (TSLPR) subunit. Recent studies indicate that TSLP and its receptor are novel therapeutic targets for rheumatoid arthritis , for increased intraarticular TSLP concentrations in patients has caused chemotaxis and activation of arthritogenic T cells.

Less than 0.1 ng/ug (1 EU/ug)

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4

Ambient

Thymic stromal lymphopoietin/TSLP