protein

Recombinant Human Ephrin A Receptor 8/EphA8 (C-Fc)

CJ80

10 ug;50 ug;500 ug;1 mg

Recombinant Protein

Recombinant Human Ephrin A Receptor 8/EphA8 (C-Fc)

Recombinant Proteins

CJ80-10ug

10 ug;50 ug;500 ug;1 mg

P29322

Ephrin type-A receptor 8 (EPHA8) is single-pass type I membrane protein. As receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. During development of the nervous system plays also a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth.

Human Cells

Ambient

Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH 7.4.

Ephrin type-A receptor 8,EEK, HEK3, KIAA1459,EPHA8,Tyrosine-protein kinase receptor EEK,hEK3,EK3,EPH-like kinase 3,EPH- and ELK-related kinase