protein

Recombinant Human GTP-Binding Protein Rheb/RHEB (N-GST)

CG22

10 ug;50 ug;500 ug;1 mg

Recombinant Protein

Recombinant Human GTP-Binding Protein Rheb/RHEB (N-GST)

Recombinant Proteins

CG22-10ug

10 ug;50 ug;500 ug;1 mg

Q15382

GTP-Binding Protein Rheb (RHEB) is a member of the small GTPase superfamily and encodes a lipid-anchored, cell membrane protein with five repeats of the RAS-related GTP-binding region. Highest levels of RHEB can be found in the skeletal and cardiac muscle, and it is vital in the regulation of growth and cell cycle progression due to its role in the Insulin/TOR/S6K signaling pathway. RHEB stimulates the phosphorylation of S6K1 and EIF4EBP1 through activation of mTORC1 signaling, and it activates the protein kinase activity of mTORC1. RHEB has GTPase activity and shuttles between a GDP-bound form and a GTP-bound form, farnesylation of the protein is required for this activity.

E. coli

Ambient

Lyophilized from a 0.2 μm filtered solution of 20mM Tris, 10mM GSH, pH 8.0.

GTP-Binding Protein Rheb, Ras Homolog Enriched in Brain, RHEB, RHEB2