protein

Recombinant Human AOC3 (C-Fc)

CA46

10 ug;50 ug;500 ug;1 mg

Recombinant Human AOC3 (C-Fc)

protein

Q16853

10 ug;50 ug;500 ug;1 mg

225

CA46-10ug

10ug;50ug;500ug;1mg

Recombinant Human Membrane primary amine oxidase is produced by our Mammalian expression system and the target gene encoding Arg28-Asn763 is expressed with a Fc tag at the C-terminus.

Human Cells

Membrane primary amine oxidase(AOC3), also known as vascular adhesion protein (VAP-1) and HPAO, this protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family. VAP-1 is a type 1 membrane-bound glycoprotein that has a distal adhesion domain and an enzymatically active amine oxidase site outside of the membrane, VAP-1 has adhesive properties, functional monoamine oxidase activity, and possibly plays a role in glucose handling, leukocyte trafficking, and migration during inflammation. This rise in metabolic products contributes to generating advanced glycation end-products and oxidative stress along with the monoamine detoxification in the organism. It is highly expressed on the endothelium of the lung and trachea, and absent from leukocytes and epithelial cells. Membrane-bound VAP-1 releases an active, soluble form of the protein, which may be conducive to increased inflammation and the progression of many vascular disorders. In particular, elevation of VAP-1 activity and the increased enzymatic-mediated deamination is proposed to play a role in renal and vascular disease, oxidative stress, acute and chronic hyperglycemia, and diabetes complications.

Less than 0.1 ng/ug (1 EU/ug)

Lyophilized from a 0.2 um filtered solution of 20mM Tris-HCl,500mM NaCl,pH 8.0

Ambient

Membrane primary amine oxidase; Copper amine oxidase; Semicarbazide-sensitive amine oxidase; Vascular adhesion protein 1; AOC3; VAP-1; SSAO; HPAO