protein

Recombinant Cynomolgus IL-4RA (C-Fc)

C939

10 ug;50 ug;500 ug;1 mg

Recombinant Cynomolgus IL-4RA (C-Fc)

protein

G7Q0S7

10 ug;50 ug;500 ug;1 mg

105

C939-10ug

10ug;50ug;500ug;1mg

Recombinant Cynomolgus Interleukin-4 Receptor Subunit Alpha is produced by our Mammalian expression system and the target gene encoding Met26-Arg232 is expressed with a Fc tag at the C-terminus.

Human Cells

Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic inflammation. In certain cell types, IL-4RA can signal through activation of insulin receptor substrates, IRS1/IRS2. The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequently it recruits to the complex of the common gamma chain. In immune cells, IL-4RA creates a type I receptor. In non-immune cells, it forms a type II receptor with of IL13RA1. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor and interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP.

Less than 0.1 ng/ug (1 EU/ug)

Lyophilized from a 0.2 um filtered solution of 20mM Tris-HCl,100mM Glycine,PH7.5

Ambient

Interleukin-4 receptor subunit alpha; IL-4R-alpha; CD124; IL4-BP; Soluble IL-4R-alpha; IL-4RA