protein

Recombinant Human Serpin A7/TBG (C-6His)

C536

10 ug;50 ug;500 ug;1 mg

Recombinant Human Serpin A7/TBG (C-6His)

protein

P05543

10 ug;50 ug;500 ug;1 mg

112

C536-10ug

10ug;50ug;500ug;1mg

Recombinant Human Serpin A7 is produced by our Mammalian expression system and the target gene encoding Ala21-Ala415 is expressed with a 6His tag at the C-terminus.

Human Cells

Serpin A7 is a secreted protein which belongs to the Serpin family. As a 54 kDa protein, Serpin A7 is synthesized primarily in the liver and secreted in plasma. Genomically, Serpin A7 is a serpin, although it has no inhibitory function like many other members of this class of proteins. Serpin A7 binds thyroid hormone in circulation. It is one of three proteins (along with transthyretin and albumin) responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. Of these three proteins, Serpin A7 has the highest affinity for T4 and T3, but is present in the lowest concentration. Despite its low concentration, Serpin A7 carries the majority of T4 in serum. Due to the very low serum concentration of T4 and T3 in the blood, Serpin A7 is rarely more than 25% saturated with its ligand. Unlike transthyretin and albumin, Serpin A7 has a single binding site for T4/T3. Serpin A7 tests are sometimes used in finding the reason for elevated or diminished levels of thyroid hormone, and defects in Serpin A7 are a cause of Serpin A7 deficiency.

Less than 0.1 ng/ug (1 EU/ug)

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4

Ambient

Thyroxine-Binding Globulin, Serpin A7, T4-Binding Globulin, SERPINA7, TBG