protein

Recombinant Human MHC Class I Polypeptide-Related Sequence A/MICA (C-6His)

C489

10 ug;50 ug;500 ug;1 mg

Recombinant Human MHC Class I Polypeptide-Related Sequence A/MICA (C-6His)

protein

Q29983

10 ug;50 ug;500 ug;1 mg

70

C489-10ug

10ug;50ug;500ug;1mg

Recombinant Human MHC Class I-related Protein A is produced by our Mammalian expression system and the target gene encoding Glu24-Gln308 is expressed with a 6His tag at the C-terminus.

Human Cells

MHC Class I Polypeptide-Related Sequence A (MICA) is a transmembrane glycoprotein that functions as a ligand for human NKG2D. Unlike classical MHC class I molecules, MICA does not form a heterodimer with beta-2-microglobulin. MICA shares 85% amino acid identity with a closely related protein, MICB. MICA acts as a stress-induced self-antigen that is recognized by NK cells, NKT cells, and most of the subtypes of T cells. As a Ligand for the KLRK1/NKG2D receptor, MICA binds to KLRK1 leads to cell lysis. MICA functions as an antigen for gamma delta T cells and is frequently expressed in epithelial tumors. MICA antigens are able to elicit the synthesis of alloantibodies in transplant recipients. Studies have shown that anti-MICA antibodies are associated with acute renal allograft rejection and failure. MICA recognition is involved in tumor surveillance, viral infections, and autoimmune diseases.

Less than 0.1 ng/ug (1 EU/ug)

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4

Ambient

MHC Class I Polypeptide-Related Sequence A, MIC-A, MICA, PERB11.1