protein

Recombinant Human Malate Dehydrogenase, Cytoplasmic/MDH1 (C-6His)

C276

10 ug;50 ug;500 ug;1 mg

Recombinant Human Malate Dehydrogenase, Cytoplasmic/MDH1 (C-6His)

protein

P40925

10 ug;50 ug;500 ug;1 mg

150

C276-10ug

10ug;50ug;500ug;1mg

Recombinant Human Malate Dehydrogenase is produced by our E.coli expression system and the target gene encoding Ser2-Ala334 is expressed with a 6His tag at the C-terminus.

E. coli

Malate Dehydrogenase, Cytoplasmic (MDH1) is an enzyme which belongs to the MDH Type 2 sub-family of LDH/MDH superfamily. MDH1 is involved in the Citric Acid Cycle that catalyzes the conversion of Malate into Oxaloacetate (using NAD+) and vice versa. MDH1 should not be confused with Malic Enzyme, which catalyzes the conversion of Malate to Pyruvate, producing NADPH. MDH1 also participates in Gluconeogenesis, the synthesis of Glucose from smaller molecules. Pyruvate in the mitochondria is acted upon by Pyruvate Carboxylase to form Pxaloacetate, a Citric Acid Cycle intermediate. In order to transport the Oxaloacetate out of the Mitochondria, Malate Dehydrogenase reduces it to Malate, and it then traverses the inner Mitochondrial membrane. Once in the cytosol, the Malate is oxidized back to Oxaloacetate by MDH1. Finally, Phosphoenol-Pyruvate Carboxy Kinase (PEPCK) converts Oxaloacetate to Phosphoenol Pyruvate.

Less than 0.1 ng/ug (1 EU/ug)

Supplied as a 0.2 μm filtered solution of 20mM Tris, 150mM NaCl, pH 8.0

Dry ice/ice packs

Malate Dehydrogenase Cytoplasmic, Cytosolic Malate Dehydrogenase, Diiodophenylpyruvate Reductase, MDH1, MDHA