product summary
Loading...
company name :
Bon Opus Biosciences
product type :
protein
product name :
Recombinant Human Apoptosis-Inducing Factor 1 Mitochondrial/AIFM1 (N-6His)
catalog :
C272
quantity :
10 ug;50 ug;500 ug;1 mg
more info or order :
Bon Opus Biosciences product webpage
product information
Cat# :
C272
Type :
Recombinant Protein
name :
Recombinant Human Apoptosis-Inducing Factor 1 Mitochondrial/AIFM1 (N-6His)
collection :
Enzymes;Recombinant Proteins
sku :
C272-10ug
productOptionDescription1 :
10 ug;50 ug;500 ug;1 mg
Accession Number :
O95831
Background :
Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. During apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces parthanatos i.e., caspase-independent fragmentation of chromosomal DNA. AIFM1 interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. It binds to DNA in a sequence-independent manner and plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells.
Expression :
E.coli
Packaging :
Ambient
Formulation :
Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.
ALTnames :
Apoptosis-Inducing Factor 1 Mitochondrial, Programmed Cell Death Protein 8, AIFM1, AIF, PDCD8
more info or order :
Bon Opus Biosciences product webpage
company information
Bon Opus Biosciences
150 Essex St. Suite 301
Millburn, NJ 07041
sales@bonopusbio.com
http://www.bonopusbio.com
1-800-943-6396
headquarters: USA
Bon Opus Biosciences is a biotech company providing essential reagents to life science community. Bon Opus is derived from the Latin "Bonum Opus," which translates to good work. We are a team of like-minded and determined individuals, all sharing a vision for success. The catalog product includes primary antibody and recombinant proteins. The scope of services offered ranges from gene synthesis to recombinant protein expression, peptide synthesis, recombinant antibody production.

Every customer is our VIP:

Flat rate charge for gene synthesis, recombinant protein production
  • Guaranteed quality
  • Flexible and care
  • Fast turnaround time
  • Affordable cost


Our reagents, your discovery!