protein

Recombinant Mouse Siglec-F (C-6His)

C07F

10 ug;50 ug;500 ug;1 mg

124 USD

Recombinant Mouse Siglec-F (C-6His)

protein

Q920G3

10 ug;50 ug;500 ug;1 mg

124 USD

C07F-10ug

10ug;50ug;500ug;1mg

Recombinant Mouse Sialic Acid-binding Ig-like Lectin 5 is produced by our Mammalian expression system and the target gene encoding Asp18-Thr437 is expressed with a 6His tag at the C-terminus.

Human Cells

Siglec 5 to 11 share a high degree of sequence similarity with CD33/Siglec-3 both in their extracellular and intracellular regions. They are collectively referred to as CD33-related Siglecs. One remarkable feature of the CD33-related Siglecs is their differential expression pattern within the hematopoietic system. This fact, together with the presence of two conserved immunoreceptor tyrosine-based inhibition motifs (ITIMs) in their cytoplasmic tails, suggests that CD33-related Siglecs are involved in the regulation of cellular activation within the immune system. Mouse Siglec-F cDNA encodes a 569 amino acid polypeptide with a hydrophobic signal peptide, an N-terminal Ig-like V-type domain, three Ig-like C2-type domains, a transmembrane region and a cytoplasmic tail. The expression of Siglec-F is restricted to the cells of myelomonocytic lineage. Mouse Siglec-F is likely an ortholog of human Siglec-5. Unlike many human CD33-related Siglecs, which show similar binding to both alpha 2,3- and alpha 2,6-linked sialic acids, mouse Siglec-F preferentially recognize alpha 2,3-linked sialic acid.

Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.

Lyophilized from a 0.2 μm filtered solution of PBS,1MmEDTA,pH7.4.

Ambient

SAF2; sialic acid binding Ig like lectin 8; SIGLEC-8; SIGLEC8L; SiglecF; Siglec-F