protein

Recombinant Human CD24 (C-Fc)

C05B

10 ug;50 ug;500 ug;1 mg

75 USD

Recombinant Human CD24 (C-Fc)

protein

P25063

10 ug;50 ug;500 ug;1 mg

75 USD

C05B-10ug

10ug;50ug;500ug;1mg

Recombinant Human Signal Transducer CD24 is produced by our Mammalian expression system and the target gene encoding Ser27-Gly 59 is expressed with a Fc tag at the C-terminus.

Human Cells

Signal Transducer CD24 is a heavily and variably glycosylated GPI-linked sialoprotein. Human CD24 is expressed on B lineage cells and granulocytes, on epithelial, neuronal, and muscle cells, and on a range of tumor cells. CD24 expression is regulated during lineage development and with the activation of various cell types. Antibody crosslinking of CD24 enhances the induction of apoptosis in B and T lymphocytes which contributes to negative selection and the induction of immune tolerance. CD24 on antigen presenting cells cooperates with B7 molecules in the costimulation of T cells. CD24 associates in cis with Siglec10 and with the danger-associated molecules HMGB1, HSP70, or HSP90 which are released from necrotic or damaged cells. Formation of these ternary complexes fills a protective role: the resulting Siglec10 signaling inhibits inflammatory responses that are otherwise induced by extracellular DAMPs.

Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.

Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Ambient

Signal transducer CD24; Small cell lung carcinoma cluster 4 antigen; CD24; CD24A