protein

Recombinant Human LR3 Insulin-Like Growth Factor I/LR3-IGF-1 (MG)

C023

10 ug;50 ug;500 ug;1 mg

Recombinant Protein

Recombinant Human LR3 Insulin-Like Growth Factor I/LR3-IGF-1 (MG)

Growth Factors;Recombinant Proteins

C023-10ug

10 ug;50 ug;500 ug;1 mg

P05019

Insulin-like growth factor I (IGF1) belongs to the family of insulin-like growth factors that are structurally homologous to proinsulin. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contains the N- and C-terminal propeptide regions. Mature human IGF-I consisting of 70 amino acids has 94% identity with mouse IGF-I and exhibits cross-species activity. IGF-1 binds IGF-IR, IGF-IIR, and the insulin receptor and plays a key role in cell cycle progression, cell proliferation and tumor progression. IGF-1 expression is regulated by growth hormone. R3 IGF-1 is an 83 amino acid analog of IGF-1 comprising the complete human IGF-1 sequence with the substitution of an Arg (R) for the Glu(E) at position three, hence R3, and a 13 amino acid extension peptide at the N terminus. R3 IGF-1 has been produced with the purpose of increasing biological activity. R3 IGF-1 is significantly more potent than human IGF-I in vitro.

E.coli

Ambient

Lyophilized from a 0.2 μm filtered solution of 300mM HAc-NaAc, pH 6.5.

Insulin-Like Growth Factor I, IGF-I, Mechano Growth Factor, MGF, Somatomedin-C, IGF1, IBP1