protein

Recombinant Human Siglec-10 (C-mFc)

C01G

10 ug;50 ug;500 ug;1 mg

Recombinant Human Siglec-10 (C-mFc)

protein

Q96LC7

10 ug;50 ug;500 ug;1 mg

71

C01G-10ug

10ug;50ug;500ug;1mg

Recombinant Human Sialic Acid-binding Ig-like Lectin 10 is produced by our Mammalian expression systemand the target gene encoding Met17-Thr546 is expressed with a mFc tag at the C-terminus.

Human Cells

Siglecs (sialic acid binding Ig-like lectins) are I-type lectins that belong to the immunoglobulin superfamily. They are characterized by an N-terminal Ig-like V-type domain which mediates sialic acid binding, followed by a varying number of Ig-like C2-type domains. Siglecs 5-11 constitute the CD33/Siglec-3 related group, and are differentially expressed in the hematopoietic system. Siglec-G is the apparent ortholog of human Siglec-10. We describe here a novel member of the siglec protein family that shares a similar structure including five Ig-like domains, a transmembrane domain, and a cytoplasmic tail containing two ITIM-signaling motifs. Siglec-10 was identified through database mining of an asthmatic eosinophil EST library. Siglec-10 binds sialated proteins and lipids in alpha 2,3 or alpha 2,6 linkage and shows a preference for GT1b gangliosides. This binding can be modulated by cis interactions of Siglec-10 with sialated molecules expressed on the same cell. When tyrosine phosphorylated, the cytoplasmic ITIMs interact with phosphatases SHP-1 and SHP-2 to propagate inhibitory signals. The Siglec-10-VAP-1 interaction seems to mediate lymphocyte adhesion to endothelium and has the potential to modify the inflammatory microenvironment via the enzymatic end products.

Less than 0.1 ng/ug (1 EU/ug)

Lyophilized from a 0.2 um filtered solution of PBS,pH7.4

Ambient

SIGLEC10; MGC126774; PRO940; Siglec10; SLG2; sialic acid-binding Ig-like lectin 10; Siglec-10;siglec-like gene 2; Siglec-like protein 2; SLG2sialic acid binding Ig-like lectin 10 Ig-like lectin 7