protein

Recombinant Cynomolgus BCMA (C-6His)

C01D

10 ug;50 ug;500 ug;1 mg

Recombinant Cynomolgus BCMA (C-6His)

protein

G7Q0I4

10 ug;50 ug;500 ug;1 mg

72

C01D-10ug

10ug;50ug;500ug;1mg

Recombinant Cynomolgus B-cell maturation protein is produced by our Mammalian expression system andthe target gene encoding Met1-Ala53 is expressed with a 6His tag at the C-terminus.

Human Cells

B cell maturation antigen (BCMA) is a member of the TNF receptor superfamily. It has been designated TNFRSF17. Mouse BCMA is a 185 amino acid (aa) protein consisting of a 49 aa extracellular domain, a 23 aa transmembrane domain, and a 113 aa intracellular domain. BCMA is a type III membrane protein containing one extracellular cysteine rich domain. Within the TNFRSF, it shares the highest homology with TACI. BCMA and TACI have both been shown to bind to APRIL and BAFF, members of the TNF ligand superfamily. BCMA expression has been found in immune organs and mature B cell lines. Although some expression has been observed at the cell surface, BCMA appears to be localized to the Golgi compartment. The binding of BCMA to APRIL or BAFF has been shown to stimulate IgM production in peripheral blood B cells and increase the survival of cultured B cells. This data suggests that BCMA may play an important role in B cell development, function and regulation.

Less than 0.1 ng/ug (1 EU/ug)

Lyophilized from a 0.2 um filtered solution of 50 mM Tris, 100 mM Glycine, pH7.5

Ambient

Tumor necrosis factor receptor superfamily member 17; B-cell maturation protein; CD269; Tnfrsf17; Bcm; Bcma