product summary
Loading...
company name :
Bon Opus Biosciences
product type :
protein
product name :
Recombinant Human Noggin/NOG
catalog :
C018
quantity :
10 ug;50 ug;500 ug;1 mg
more info or order :
Bon Opus Biosciences product webpage
product information
Cat# :
C018
Type :
Recombinant Protein
name :
Recombinant Human Noggin/NOG
collection :
Recombinant Proteins
sku :
C018-10ug
productOptionDescription1 :
10 ug;50 ug;500 ug;1 mg
Accession Number :
Q13253
Background :
Noggin is a secreted homodimeric glycoprotein that is an antagonist of bone morphogenetic proteins (BMPs). Mature Human Noggin contains an N-terminal acidic region, a central basic heparin-binding segment and a C-terminal cysteine-knot structure. Noggin is very highly conserved among vertebrates, such that mature human Noggin shares 99%, 99%, 98%, 97% and 89% aa sequence identity with mouse, rat bovine, equine and chicken Noggin, respectively. Secreted Noggin probably remains close to the cell surface due to its binding of heparin-containing proteoglycans. Noggin binds some BMPs such as BMP4 with high affinity and others such as BMP7 with lower affinity. It antagonizes BMP bioactivities by blocking epitopes on BMPs that are needed for binding to both type I and type II receptors. Noggin is expressed in defined areas of the adult central nervous system and peripheral tissues such as lung, skeletal muscle and skin. During culture of human embryonic stem cells (hESC) or neural stem cells under certain conditions, addition of Noggin to antagonize BMP activity may allow stem cells to proliferate while maintaining their undifferentiated state, or alternatively, to differentiate into dopaminergic neurons.
Expression :
Human Cells
Packaging :
Ambient
Formulation :
Lyophilized from a 0.2 μm filtered solution of 20mM PB,500mM NaCl,2mM EDTA,pH7.4.
ALTnames :
Noggin; NOG
more info or order :
Bon Opus Biosciences product webpage
company information
Bon Opus Biosciences
150 Essex St. Suite 301
Millburn, NJ 07041
sales@bonopusbio.com
http://www.bonopusbio.com
1-800-943-6396
headquarters: USA
Bon Opus Biosciences is a biotech company providing essential reagents to life science community. Bon Opus is derived from the Latin "Bonum Opus," which translates to good work. We are a team of like-minded and determined individuals, all sharing a vision for success. The catalog product includes primary antibody and recombinant proteins. The scope of services offered ranges from gene synthesis to recombinant protein expression, peptide synthesis, recombinant antibody production.

Every customer is our VIP:

Flat rate charge for gene synthesis, recombinant protein production
  • Guaranteed quality
  • Flexible and care
  • Fast turnaround time
  • Affordable cost


Our reagents, your discovery!