protein

Recombinant Human SIRP alpha/CD172a (C-His)

BP229

10 ug;50 ug;500 ug;1 mg

70 USD

Recombinant Human SIRP alpha/CD172a (C-His)

protein

P78324

10 ug;50 ug;500 ug;1 mg

70

BP229-10ug

70 USD

10ug;50ug;500ug;1mg

Recombinant Human SIRP alpha is produced by our Mammalian expression system and the target gene encoding Glu31-Arg370 is expressed with a 6His tag at the C-terminus.

Human 293 Cells

Signal regulatory protein alpha (SIRPα) is a monomeric type I transmembrane glycoprotein, that belongs to the SIRP/SHPS (CD172) family of the immunoglobulin superfamily. SIRPα can express in a variety of tissues, mainly in brain and myeloid cells, such as macrophages, neutrophils, dendritic and Langerhans cells. It is also found in neurons, smooth muscle and endothelial cells. SIRPα is an immunoglobulin-like cell surface receptor for CD47. Its binding to CD47 prevents the maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. SIRPα also acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPα holds the adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a critical role in intracellular signaling during synaptogenesis and in synaptic function.

Less than 0.1 EU/ug

Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4

Ambient

SHP Substrate 1; SHPS-1; CD172 Antigen-Like Family Member A; Inhibitory Feceptor SHPS-1; Macrophage Fusion Receptor; MyD-1 Antigen; Signal-Regulatory Protein Alpha-1; Sirp-Alpha-1; Sirp-Alpha-2; Signal-Regulatory Protein Alpha-3; Sirp-Alpha-3; p84; CD172a; SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP