protein

Recombinant Human Tau Protein (Mammalian expressed, N-His)

BP228

10 ug;50 ug;500 ug;1 mg

105 USD

Recombinant Human Tau Protein (Mammalian expressed, N-His)

protein

P10636-8

10 ug;50 ug;500 ug;1 mg

105

BP228-10ug

105 USD

10ug;50ug;500ug;1mg

Recombinant Human Tau protein is produced by our Mammalian expression system and the target gene encoding Ala2-Leu441 is expressed with a 6His tag at the N-terminus.

Human Cells

Tau is a microtubule-associated protein expressed primarily in neurons. Tau promotes the assembly and stabilization of microtubules along with other MAP proteins. It is thought that other proteins can compensate for loss of Tau protein function as Tau knockout mice are viable and show no signs of neurodegeneration. There are multiple isoforms of Tau created by alternative splicing of exons 2, 3, and 10. When tau proteins are defective and no longer stabilize microtubules properly, they can result in several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.

Less than 0.1 EU/ug

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Ambient

Microtubule-associated protein tau; MAPTL; Neurofibrillary tangle protein; MTBT1; Paired helical filament-tau; MAPT; Tau-F; MAPT-F