protein

Recombinant Human PSD95/Disks large homolog 4/DLG4(N-His)

BP196

10 ug;50 ug;500 ug;1 mg

105 USD

Recombinant Human PSD95/Disks large homolog 4/DLG4(N-His)

protein

P78352

10 ug;50 ug;500 ug;1 mg

105

BP196-10ug

105 USD

10ug;50ug;500ug;1mg

Recombinant Human PSD95 is produced by our E.coli expression system and the target gene encoding Met1-Leu724 is expressed with a 6His tag at the N-terminus.

E.coli

Postsynaptic density protein 95 (PSD-95), also known as disks large homolog 4(DLG4) is a cell membrane protein that is a member of the membrane-associated guanylate kinase (MAGUK) family. DLG4 is recruited into the same NMDA receptor and potassium channel clusters as PSD-93. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. DLG4 is the best-studied member of the MAGUK-family of PDZ domain-containing proteins. It is nearly exclusively located in the post-synaptic density of neurons and plays a role in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels. DLG4 is also involved in synaptic plasticity and the stabilization of synaptic changes during long-term potentiation. A recent study showed that clinical manifestations associated with DLG4 overlapping with those found in other neurodevelopmental disorders of synaptic dysfunction.

Less than 1 EU/ug

Lyophilized from a 0.2 um filtered solution of PBS, pH7.4

Ambient

Disks large homolog 4; Postsynaptic density protein 95; PSD-95; Synapse-associated protein90; SAP-90; SAP90; PSD95; DLG4