protein

Recombinant Human IL-3R alpha/CD123(C-hFc)

BP123

50 ug;500 ug

Recombinant Human IL-3R alpha/CD123(C-hFc)

protein

P26951

50 ug;500 ug

315

BP123-50ug

50ug;500ug

Recombinant Human Interleukin-3 Receptor Subunit Alpha is produced by our Mammalian expression systemand the target gene encoding Lys20-Arg305 is expressed with a Fc tag at the C-terminus.

Human 293 Cells

CD123, also known as Interleukin-3 receptor subunit alpha, is a glycoprotein that belongs to the type I cytokine receptor family. CD123 is a heterodimer with an alpha and a beta subunit. The alpha subunit alone binds IL‑3 with low affinity. The beta subunit does not bind IL‑3 by itself but is required for the high‑affinity binding of IL‑3 to the heterodimeric receptor complex. CD123 induces the proliferation and differentiation of hemopoietic cells including the pluripotent hematopoietic stem cells as well as a variety of lineage‑committed cells. CD123 has been identified as a potential immunotherapeutic target due to its overexpression in AML compared with normal hematopoietic stem cells.

Less than 0.1 EU/ug

Lyophilized from a 0.2 um filtered solution of PBS, pH 7.4

Ambient

Interleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha;IL-3RA; IL3RA;CD123