This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Bioss
product type :
antibody
product name :
STAT1 (7G8) Monoclonal Antibody
catalog :
bsm-33273M
quantity :
100 ul
price :
289.5 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
7G8
reactivity :
human, rat
application :
immunocytochemistry, immunohistochemistry - paraffin section
product information
sku :
bsm-33273M
name :
STAT1 (7G8) Monoclonal Antibody
category :
Primary Antibody
conjugation :
Unconjugated
host :
Mouse
target protein :
STAT1
modification :
Unmodified
clonality :
Monoclonal
clone number :
7G8
isotype :
IgG
concentration :
1ug/ul
public immunogen range :
680-715/750
source :
KLH conjugated synthetic peptide derived from human STAT1
gene id link :
Entrez Gene: 6772
swiss prot :
P42224
swiss prot link :
Swiss Prot: P42224
applications :
IHC-P, IF(IHC-P)
applications with dilutions :
IHC-P(1:100-500), IF(IHC-P)(1:50-200)
cross reactive species :
Human, Rat
size :
100 ul
price :
289.5 USD
background :
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
purification :
Purified by Protein G.
storage :
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
synonyms :
Signal transducer and activator of transcription 1-alpha/beta; STAT1; Transcription factor ISGF-3 components p91/p84
lead time :
3 to 5 business days.
company information
Bioss
500 West Cummings Park
Suite 6500
Woburn, MA 01801
info@biossusa.com
http://biossusa.com
800-501-7654
headquarters: USA
Bioss Inc is a leading antibody developer and manufacturer with state of the art technologies. We have developed over 11,000 antigens/primary antibodies and more than 130,000 derived products including fluorochrome conjugated antibodies. In addition to reliable loading control and tag antibodies, our catalog includes over 1000 specific antibodies recognizing proteins with phosphorylation, acetylation, or methylation modifications. Our company promises fast delivery with strong, top quality scientific support. Bioss Inc is located in the greater Boston area of Massachusetts, the center of the world's largest and fastest growing biotech community.