Caspase-8 subunit p18 Antibody | Bioss bs-6463R product information

product summary

company name :

Bioss

product type :

antibody

product name :

Caspase-8 subunit p18 Antibody

catalog :

bs-6463R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
ELISA; human	Shan M, Fan T. Cytotoxicity of carteolol to human corneal epithelial cells by inducing apoptosis via triggering the Bcl-2 family protein-mediated mitochondrial pro-apoptotic pathway. Toxicol In Vitro. 2016;35:36-42 pubmed publisher
ELISA; human	Zhao J, Qiu Y, Tian C, Fan T. The cytotoxic and pro-apoptotic effects of phenylephrine on corneal stromal cells via a mitochondrion-dependent pathway both in vitro and in vivo. Exp Toxicol Pathol. 2016;68:409-17 pubmed publisher
immunocytochemistry; mouse	Bozok Cetintaş V, Acikgoz E, Yigitturk G, Demir K, Oktem G, Tezcanli Kaymaz B, et al. Effects of flavopiridol on critical regulation pathways of CD133high/CD44high lung cancer stem cells. Medicine (Baltimore). 2016;95:e5150 pubmed
western blot; mouse	Meneses C, Morales M, Abrigo J, Simon F, Brandan E, Cabello-Verrugio C. The angiotensin-(1-7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice. Pflugers Arch. 2015;467:1975-84 pubmed publisher

product information

sku :

bs-6463R

name :

Caspase-8 subunit p18 Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

Caspase-8 subunit p18

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

217-244/479

subcellular locations :

Cytoplasm

source :

KLH conjugated synthetic peptide derived from human Caspase-8 subunit p18

gene id link :

Entrez Gene: 841

swiss prot :

Q14790

swiss prot link :

Swiss Prot: Q14790

applications :

WB, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp- -AMC. Likely target for the cowpox virus CRMA death inhibitory protein. Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic site and may interfere with the pro-apoptotic activity of the complex.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8; Caspase-8; Apoptotic cysteine protease; Apoptotic protease Mch-5; FADD-homologous ICE/ced-3-like protease; FADD-like ICE; ICE-like apoptotic protease 5; MORT1-associated ced-3 homolog; CASP8

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage