PRKCQ(Thr538) Polyclonal Antibody | Bioss bs-5585R product information

product summary

company name :

Bioss

product type :

antibody

product name :

PRKCQ(Thr538) Polyclonal Antibody

catalog :

bs-5585R

quantity :

100 ul

price :

299 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human	van Rees G, Lago S, Cox D, Tomasik J, Rustogi N, Weigelt K, et al. Evidence of microglial activation following exposure to serum from first-onset drug-naïve schizophrenia patients. Brain Behav Immun. 2018;67:364-373 pubmed publisher

product information

sku :

bs-5585R

name :

PRKCQ(Thr538) Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

PRKCQ Thr538

modification :

Phosphorylation

modification site :

Thr538

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

532-540/706

subcellular locations :

Cytoplasm

source :

KLH conjugated synthetic phosphopeptide derived from human PRKCQ around the phosphorylation site of Thr538

gene id link :

Entrez Gene: 5588

swiss prot :

Q04759

swiss prot link :

Swiss Prot: Q04759

applications :

WB, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

299 USD

background :

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that mediates non-redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors such as NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is required for the activation of NF-kappa-B and JUN, which in turn are essential for IL2 production, and participates to the calcium-dependent NFATC1 and NFATC2 transactivation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, inducing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. May also play an indirect role in activation of the non-canonical NF-kappa-B (NFKB2) pathway. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling. Plays a critical role in TCR/CD28-induced NFATC1 and NFATC2 transactivation by participating in the regulation of reduced inositol 1,4,5-trisphosphate generation and intracellular calcium mobilization. After costimulation of T-cells through CD28 can phosphorylate CBLB and is required for the ubiquitination and subsequent degradation of CBLB, which is a prerequisite for the activation of TCR. During T-cells differentiation, plays an important role in the development of T-helper 2 (Th2) cells following immune and inflammatory responses, and, in the development of inflammatory autoimmune diseases, is necessary for the activation of IL17-producing Th17 cells. May play a minor role in Th1 response.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

PRKCT; nPKC-theta; Protein kinase C theta type; PRKCQ

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage