AGER Polyclonal Antibody | Bioss bs-4999R product information

product summary

company name :

Bioss

product type :

antibody

product name :

AGER Polyclonal Antibody

catalog :

bs-4999R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, other

more info or order :

Bioss product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; rat	Qiu Y, Tang L, Wei W. Berberine exerts renoprotective effects by regulating the AGEs-RAGE signaling pathway in mesangial cells during diabetic nephropathy. Mol Cell Endocrinol. 2017;: pubmed publisher
flow cytometry; human	Durning S, Preston-Hurlburt P, Clark P, Xu D, Herold K. The Receptor for Advanced Glycation Endproducts Drives T Cell Survival and Inflammation in Type 1 Diabetes Mellitus. J Immunol. 2016;197:3076-3085 pubmed
other; human	Guan S, Sheu M, Wu C, Chiang C, Liu S. ATP synthase subunit-β down-regulation aggravates diabetic nephropathy. Sci Rep. 2015;5:14561 pubmed publisher

product information

sku :

bs-4999R

name :

AGER Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

AGER

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

30-80/404

subcellular locations :

Extracellular

source :

KLH conjugated synthetic peptide derived from human AGER

gene id link :

Entrez Gene: 177

swiss prot :

Q15109

swiss prot link :

Swiss Prot: Q15109

applications :

WB, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

Mediates interactions of advanced glycosylation end products (AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide (ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase (MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

RAGE; Advanced glycosylation end product-specific receptor; Receptor for advanced glycosylation end products; AGER

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage