IGF1R Polyclonal Antibody | Bioss bs-4985R product information

product summary

company name :

Bioss

product type :

antibody

product name :

IGF1R Polyclonal Antibody

catalog :

bs-4985R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, sheep

application :

western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human	Chu M, Zhao Y, Feng Y, Zhang H, Liu J, Cheng M, et al. MicroRNA-126 participates in lipid metabolism in mammary epithelial cells. Mol Cell Endocrinol. 2017;454:77-86 pubmed publisher
western blot; sheep; loading ...; fig 6a	Zhao Y, Feng Y, Zhang H, Kou X, Li L, Liu X, et al. Inhibition of peripubertal sheep mammary gland development by cysteamine through reducing progesterone and growth factor production. Theriogenology. 2017;89:280-288 pubmed publisher

product information

sku :

bs-4985R

name :

IGF1R Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

IGF1R

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

850-900/1367

subcellular locations :

Extracellular

source :

KLH conjugated synthetic peptide derived from human IGF1R/CD221 beta chain

gene id link :

Entrez Gene: 3480

swiss prot :

P08069

swiss prot link :

Swiss Prot: P08069

applications :

WB, FCM, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), FCM(1:20-100), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

IGFR; CD221; IGFIR; JTK13; Insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; IGF1R

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage