PPAR Gamma (ser273) Polyclonal Antibody | Bioss bs-4888R product information

product summary

company name :

Bioss

product type :

antibody

product name :

PPAR Gamma (ser273) Polyclonal Antibody

catalog :

bs-4888R

quantity :

100 ul

price :

309.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

Guinea, human, mouse, rat, pig

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 9

Published Application/Species/Sample/Dilution	Reference
western blot; rat	Liu L, Wan J, Lang H, Si M, Zhu J, Zhou Y, et al. Dihydromyricetin delays the onset of hyperglycemia and ameliorates insulin resistance without excessive weight gain in Zucker diabetic fatty rats. Mol Cell Endocrinol. 2016;: pubmed publisher
western blot; mouse	Maganti A, Tersey S, Syed F, Nelson J, Colvin S, Maier B, et al. Peroxisome Proliferator-activated Receptor-γ Activation Augments the β-Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and β Cell Death in Non-obese Diabetic Mice. J Biol Chem. 2016;291:22524-22533 pubmed
western blot; mouse	Abd Alla J, Graemer M, Fu X, Quitterer U. Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice. J Biol Chem. 2016;291:2583-600 pubmed publisher
immunohistochemistry - paraffin section; rat	Agrawal S, Chanley M, Westbrook D, Nie X, Kitao T, Guess A, et al. Pioglitazone Enhances the Beneficial Effects of Glucocorticoids in Experimental Nephrotic Syndrome. Sci Rep. 2016;6:24392 pubmed publisher
western blot; mouse	Stechschulte L, Ge C, Hinds T, SANCHEZ E, Franceschi R, Lecka-Czernik B. Protein Phosphatase PP5 Controls Bone Mass and the Negative Effects of Rosiglitazone on Bone through Reciprocal Regulation of PPARγ (Peroxisome Proliferator-activated Receptor γ) and RUNX2 (Runt-related Transcription Factor 2). J Biol Chem. 2016;291:24475-24486 pubmed
western blot; mouse	Liu C, Feng T, Zhu N, Liu P, Han X, Chen M, et al. Identification of a novel selective agonist of PPARγ with no promotion of adipogenesis and less inhibition of osteoblastogenesis. Sci Rep. 2015;5:9530 pubmed publisher
western blot; pig western blot; Guinea	Sarr O, Thompson J, Zhao L, Lee T, Regnault T. Low birth weight male guinea pig offspring display increased visceral adiposity in early adulthood. PLoS ONE. 2014;9:e98433 pubmed publisher
western blot; mouse	Kolli V, Stechschulte L, Dowling A, Rahman S, Czernik P, Lecka-Czernik B. Partial agonist, telmisartan, maintains PPARγ serine 112 phosphorylation, and does not affect osteoblast differentiation and bone mass. PLoS ONE. 2014;9:e96323 pubmed publisher
western blot; mouse	Pandurangan M, Park J, Kim E. Aspartame downregulates 3T3-L1 differentiation. In Vitro Cell Dev Biol Anim. 2014;50:851-7 pubmed publisher

product information

sku :

bs-4888R

name :

PPAR Gamma (ser273) Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

PPAR Gamma ser273

modification :

Phosphorylation

modification site :

ser273

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

250-300/505

subcellular locations :

Cytoplasm, Nucleus

source :

KLH conjugated synthetic phosphopeptide derived from human PPAR Gamma around the phosphorylation site of ser273

gene id link :

Entrez Gene: 5468

swiss prot :

P37231

swiss prot link :

Swiss Prot: P37231

applications :

WB, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

309.5 USD

background :

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma; Peroxisome proliferator-activated receptor gamma; PPAR-gamma; Nuclear receptor subfamily 1 group C member 3; PPARG

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage