Complement C3 beta chain Antibody | Bioss bs-4871R product information

product summary

company name :

Bioss

product type :

antibody

product name :

Complement C3 beta chain Antibody

catalog :

bs-4871R

quantity :

100 ul

price :

279 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Bioss product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse	Magliarelli H, Matondo M, MÃ©szÃ¡ros G, Goginashvili A, Erbs E, Zhang Z, et al. Liver ubiquitome uncovers nutrient-stress-mediated trafficking and secretion of complement C3. Cell Death Dis. 2016;7:e2411 pubmed publisher

product information

sku :

bs-4871R

name :

Complement C3 beta chain Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

Complement C3 beta chain

specificity :

This antibody could recognize C3-beta-c

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

585-635/1663

subcellular locations :

Secreted

source :

KLH conjugated synthetic peptide derived from human Complement C3 beta chain

gene id link :

Entrez Gene: 718

swiss prot :

P01024

swiss prot link :

Swiss Prot: P01024

applications :

WB, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

279 USD

background :

C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalization and recycling of C5AR2 (PubMed:8376604, PubMed:2909530, PubMed:9059512, PubMed:10432298, PubMed:15833747, PubMed:16333141, PubMed:19615750).

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

ASP; C3a; C3b; AHUS5; ARMD9; CPAMD1; HEL-S-62p; Complement C3; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1; C3

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage