DNA PK/PRKDC(Ser2056) Antibody | Bioss bs-3734R product information

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product summary

company name :

Bioss

product type :

antibody

product name :

DNA PK/PRKDC(Ser2056) Antibody

catalog :

bs-3734R

quantity :

100 ul

price :

299 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

immunocytochemistry, immunohistochemistry - paraffin section

product information

sku :

bs-3734R

name :

DNA PK/PRKDC(Ser2056) Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

DNA PK/PRKDC Ser2056

specificity :

This phosphorylation site is homologous to that of Ser2053 in Mouse and Ser2051 in Rat.

modification :

Phosphorylation

modification site :

Ser2056

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

2030-2080/4128

subcellular locations :

Nucleus

source :

KLH conjugated synthetic phosphopeptide derived from human DNA PK around the phosphorylation site of Ser2056

gene id link :

Entrez Gene: 5591

swiss prot :

P78527

swiss prot link :

Swiss Prot: P78527

applications :

IHC-P, IF(IHC-P)

applications with dilutions :

IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

299 USD

background :

Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect machanism. Interacts with CRY1 and CRY2; negatively regulates CRY1 phosphorylation.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

HYRC; p350; DNAPK; DNPK1; HYRC1; IMD26; XRCC7; DNA-PKcs; DNA-dependent protein kinase catalytic subunit; DNA-PK catalytic subunit; p460; PRKDC

lead time :

3 to 5 business days.