product summary
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company name :
Bioss
product type :
antibody
product name :
KEAP1 Polyclonal Antibody
catalog :
bs-3648R
quantity :
100 ul
price :
289.5 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, rabbit
application :
western blot, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Bioss product webpage
citations: 4
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; rabbit
  • western blot; rabbit
Chen Y, Lin W, Liu C, Hsu L, Lin Y, Su S. Caveolin-1 Expression Ameliorates Nephrotic Damage in a Rabbit Model of Cholesterol-Induced Hypercholesterolemia. PLoS ONE. 2016;11:e0154210 pubmed publisher
  • western blot; human
Su C, Xia X, Shi Q, Song X, Fu J, Xiao C, et al. Neohesperidin Dihydrochalcone versus CClâ‚„-Induced Hepatic Injury through Different Mechanisms: The Implication of Free Radical Scavenging and Nrf2 Activation. J Agric Food Chem. 2015;63:5468-75 pubmed publisher
  • western blot; human
Su C, Zhang P, Song X, Shi Q, Fu J, Xia X, et al. Tetrachlorobenzoquinone activates Nrf2 signaling by Keap1 cross-linking and ubiquitin translocation but not Keap1-Cullin3 complex dissociation. Chem Res Toxicol. 2015;28:765-74 pubmed publisher
Su C, Liu Z, Wang Y, Wang Y, Song E, Song Y. The electrophilic character of quinones is essential for the suppression of Bach1. Toxicology. 2017;387:17-26 pubmed publisher
product information
sku :
bs-3648R
name :
KEAP1 Polyclonal Antibody
category :
Primary Antibody
conjugation :
Unconjugated
host :
Rabbit
target protein :
KEAP1
modification :
Unmodified
clonality :
Polyclonal
isotype :
IgG
concentration :
1ug/ul
public immunogen range :
75-125/624
subcellular locations :
Cytoplasm, Nucleus
source :
KLH conjugated synthetic peptide derived from human KEAP1
gene id link :
Entrez Gene: 9817
swiss prot :
Q14145
swiss prot link :
Swiss Prot: Q14145
applications :
WB, IHC-P, IF(IHC-P)
applications with dilutions :
WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
cross reactive species :
Human, Mouse, Rat
size :
100 ul
price :
289.5 USD
background :
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
purification :
Purified by Protein A.
storage :
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
synonyms :
INrf2; KLHL19; Kelch-like ECH-associated protein 1; Cytosolic inhibitor of Nrf2; Kelch-like protein 19; KEAP1; KIAA0132
lead time :
3 to 5 business days.
more info or order :
Bioss product webpage
company information
Bioss
500 West Cummings Park
Suite 6500
Woburn, MA 01801
info@biossusa.com
biossusa.com
800-501-7654
headquarters: USA
Bioss Inc is a leading antibody developer and manufacturer with state of the art technologies. We have developed over 11,000 antigens/primary antibodies and more than 130,000 derived products including fluorochrome conjugated antibodies. In addition to reliable loading control and tag antibodies, our catalog includes over 1000 specific antibodies recognizing proteins with phosphorylation, acetylation, or methylation modifications. Our company promises fast delivery with strong, top quality scientific support. Bioss Inc is located in the greater Boston area of Massachusetts, the center of the world's largest and fastest growing biotech community.