Smad2/3 Polyclonal Antibody | Bioss bs-3484R product information

product summary

company name :

Bioss

product type :

antibody

product name :

Smad2/3 Polyclonal Antibody

catalog :

bs-3484R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, pig

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; pig	Bai L, Chu G, Wang W, Xiang A, Yang G. BAMBI promotes porcine granulosa cell steroidogenesis involving TGF-β signaling.. Theriogenology. 2017;100:24-31 pubmed publisher
western blot; human	Liu Y, Zou J, Li B, Wang Y, Wang D, Hao Y, et al. RUNX3 modulates hypoxia-induced endothelial-to-mesenchymal transition of human cardiac microvascular endothelial cells.. Int J Mol Med. 2017;40:65-74 pubmed publisher
western blot; mouse; 1:500; fig 3	Wang Z, Zhang H, Sun X, Ren L. The protective role of vitamin D3 in a murine model of asthma via the suppression of TGF-β/Smad signaling and activation of the Nrf2/HO-1 pathway. Mol Med Rep. 2016;14:2389-96 pubmed publisher
immunohistochemistry - paraffin section; mouse	Wahsh E, Abu-Elsaad N, El-Karef A, Ibrahim T. The vitamin D receptor agonist, calcipotriol, modulates fibrogenic pathways mitigating liver fibrosis in-vivo: An experimental study. Eur J Pharmacol. 2016;789:362-9 pubmed publisher
western blot; rat; loading ...; fig 3d	Gao L, Tang H, He H, Liu J, Mao J, Ji H, et al. Glycyrrhizic acid alleviates bleomycin-induced pulmonary fibrosis in rats. Front Pharmacol. 2015;6:215 pubmed publisher

product information

sku :

bs-3484R

name :

Smad2/3 Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

Smad2/3

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

30-80/467

subcellular locations :

Cytoplasm, Nucleus

source :

KLH conjugated synthetic peptide derived from human Smad2

gene id link :

Entrez Gene: 40,874,088

swiss prot :

Q15796

swiss prot link :

Swiss Prot: Q15796

applications :

WB, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

JV18; MADH2; MADR2; JV18-1; hMAD-2; hSMAD2; LDS3; LDS1C; MADH3; JV15-2; HSPC193; HsT17436; Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; Mad-related protein 2; SMAD family member 2; SMAD 2; Smad2

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage