product summary
company name :
Bioss
product type :
antibody
product name :
PKC alpha/beta 2 (Thr638/641) Antibody
catalog :
bs-3333R
quantity :
100 ul
price :
309.5 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dog
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Bioss product webpage
citations: 2
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; 1:100; loading ...; fig 1a
Edens L, Dilsaver M, Levy D. PKC-mediated phosphorylation of nuclear lamins at a single serine residue regulates interphase nuclear size in Xenopus and mammalian cells. Mol Biol Cell. 2017;28:1389-1399 pubmed publisher
Edens L, Levy D. cPKC regulates interphase nuclear size during Xenopus development. J Cell Biol. 2014;206:473-83 pubmed publisher
product information
sku :
bs-3333R
name :
PKC alpha/beta 2 (Thr638/641) Antibody
category :
Primary Antibody
conjugation :
Unconjugated
host :
Rabbit
target protein :
PKC alpha/beta 2 Thr638/641
modification :
Phosphorylation
modification site :
Thr638/641
clonality :
Polyclonal
isotype :
IgG
concentration :
1ug/ul
public immunogen range :
606-641/672
subcellular locations :
Cytoplasm
source :
KLH conjugated synthetic phosphopeptide derived from human PKC alpha/beta II around the phosphorylation site of Thr638/641
gene id link :
Entrez Gene: 5578
swiss prot :
P17252
swiss prot link :
Swiss Prot: P17252
applications :
WB, IHC-P, IF(IHC-P)
applications with dilutions :
WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
cross reactive species :
Human, Mouse, Rat, Dog
size :
100 ul
price :
309.5 USD
background :
Protein Kinase c alpha (PKC alpha) is an 77 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide dependent kinase 1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.
purification :
Purified by Protein A.
storage :
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
synonyms :
AAG6; PKCA; PRKACA; PKC-alpha; Protein kinase C alpha type; PKC-A; PRKCA
lead time :
3 to 5 business days.
more info or order :
Bioss product webpage
company information
Bioss
500 West Cummings Park
Suite 6500
Woburn, MA 01801
info@biossusa.com
http://biossusa.com
800-501-7654
headquarters: USA
Bioss Inc is a leading antibody developer and manufacturer with state of the art technologies. We have developed over 11,000 antigens/primary antibodies and more than 130,000 derived products including fluorochrome conjugated antibodies. In addition to reliable loading control and tag antibodies, our catalog includes over 1000 specific antibodies recognizing proteins with phosphorylation, acetylation, or methylation modifications. Our company promises fast delivery with strong, top quality scientific support. Bioss Inc is located in the greater Boston area of Massachusetts, the center of the world's largest and fastest growing biotech community.