PERK(Thr980) Polyclonal Antibody | Bioss bs-3330R product information

product summary

company name :

Bioss

product type :

antibody

product name :

PERK(Thr980) Polyclonal Antibody

catalog :

bs-3330R

quantity :

100 ul

price :

309.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, pig

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot; pig	Mak S, Yu C, Sun W, He G, Liu X, Yang Q. Tetramethylpyrazine suppresses angiotensin II-induced soluble epoxide hydrolase expression in coronary endothelium via anti-ER stress mechanism. Toxicol Appl Pharmacol. 2017;336:84-93 pubmed publisher
immunocytochemistry; human western blot; human	Carmosino M, Gerbino A, Schena G, Procino G, Miglionico R, Forleo C, et al. The expression of Lamin A mutant R321X leads to endoplasmic reticulum stress with aberrant Ca2+ handling. J Cell Mol Med. 2016;20:2194-2207 pubmed publisher
immunocytochemistry; mouse	Chen Y, Holstein D, Aime S, Bollo M, Lechleiter J. Calcineurin Î² protects brain after injury by activating the unfolded protein response. Neurobiol Dis. 2016;94:139-56 pubmed publisher
western blot; rat	Yu H, Zhang H, Zhao W, Guo L, Li X, Li Y, et al. Gypenoside Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting Cardiomyocytes Apoptosis via Inhibition of CHOP Pathway and Activation of PI3K/Akt Pathway In Vivo and In Vitro. Cell Physiol Biochem. 2016;39:123-36 pubmed publisher
western blot; human	Xu D, Su C, Song X, Shi Q, Fu J, Hu L, et al. Polychlorinated biphenyl quinone induces endoplasmic reticulum stress, unfolded protein response, and calcium release. Chem Res Toxicol. 2015;28:1326-37 pubmed publisher
western blot; rat	Aslan M, Basaranlar G, Unal M, Ciftcioglu A, Derin N, Mutus B. Inhibition of neutral sphingomyelinase decreases elevated levels of inducible nitric oxide synthase and apoptotic cell death in ocular hypertensive rats. Toxicol Appl Pharmacol. 2014;280:389-98 pubmed publisher
western blot; human	Kucuksayan E, Konuk E, Demir N, Mutus B, Aslan M. Neutral sphingomyelinase inhibition decreases ER stress-mediated apoptosis and inducible nitric oxide synthase in retinal pigment epithelial cells. Free Radic Biol Med. 2014;72:113-23 pubmed publisher
western blot; human	He Y, Long J, Zhong W, Fu Y, Li Y, Lin S. Sustained endoplasmic reticulum stress inhibits hepatocyte proliferation via downregulation of c-Met expression. Mol Cell Biochem. 2014;389:151-8 pubmed publisher

product information

sku :

bs-3330R

name :

PERK(Thr980) Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

PERK Thr980

modification :

Phosphorylation

modification site :

Thr980

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

960-1010/1114

subcellular locations :

Cytoplasm

source :

KLH conjugated synthetic phosphopeptide derived from mouse PERK around the phosphorylation site of Thr981

gene id link :

Entrez Gene: 13666

swiss prot :

Q9Z2B5

swiss prot link :

Swiss Prot: Q9Z2B5

applications :

WB, IHC-P, IF(IHC-P), IF(ICC)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

309.5 USD

background :

Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

Pek; Perk; AI427929; Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; Eif2ak3

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage