product summary
company name :
Bioss
product type :
antibody
product name :
LRP6 (Ser1490) Polyclonal Antibody
catalog :
bs-3253R
quantity :
100 ul
price :
309.5 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Bioss product webpage
citations: 4
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human
Boone J, Arend R, Johnston B, Cooper S, Gilchrist S, Oelschlager D, et al. Targeting the Wnt/β-catenin pathway in primary ovarian cancer with the porcupine inhibitor WNT974. Lab Invest. 2016;96:249-59 pubmed publisher
Xiao L, Fei Y, Hurley M. FGF2 crosstalk with Wnt signaling in mediating the anabolic action of PTH on bone formation. Bone Rep. 2018;9:136-144 pubmed publisher
Meo Burt P, Xiao L, Hurley M. FGF23 Regulates Wnt/β-Catenin Signaling-Mediated Osteoarthritis in Mice Overexpressing High-Molecular-Weight FGF2. Endocrinology. 2018;159:2386-2396 pubmed publisher
Chen Z, Xu J, Ye Y, Li Y, Gong H, Zhang G, et al. Urotensin II inhibited the proliferation of cardiac side population cells in mice during pressure overload by JNK-LRP6 signalling. J Cell Mol Med. 2014;18:852-62 pubmed publisher
product information
sku :
bs-3253R
name :
LRP6 (Ser1490) Polyclonal Antibody
category :
Primary Antibody
conjugation :
Unconjugated
host :
Rabbit
target protein :
LRP6 Ser1490
modification :
Phosphorylation
modification site :
Ser1490
clonality :
Polyclonal
isotype :
IgG
concentration :
1ug/ul
public immunogen range :
1470-1520/1613
subcellular locations :
Cytoplasm
source :
KLH conjugated synthetic phosphopeptide derived from human LRP6 around the phosphorylation site of Ser1490
gene id link :
Entrez Gene: 4040
swiss prot :
O75581
swiss prot link :
Swiss Prot: O75581
applications :
IHC-P, IF(IHC-P), IF(ICC)
applications with dilutions :
IHC-P(1:100-500), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)
cross reactive species :
Human, Mouse
size :
100 ul
price :
309.5 USD
background :
Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity).
purification :
Purified by Protein A.
storage :
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
synonyms :
ADCAD2; Low-density lipoprotein receptor-related protein 6; LRP-6; LRP6
lead time :
3 to 5 business days.
more info or order :
Bioss product webpage
company information
Bioss
500 West Cummings Park
Suite 6500
Woburn, MA 01801
info@biossusa.com
http://biossusa.com
800-501-7654
headquarters: USA
Bioss Inc is a leading antibody developer and manufacturer with state of the art technologies. We have developed over 11,000 antigens/primary antibodies and more than 130,000 derived products including fluorochrome conjugated antibodies. In addition to reliable loading control and tag antibodies, our catalog includes over 1000 specific antibodies recognizing proteins with phosphorylation, acetylation, or methylation modifications. Our company promises fast delivery with strong, top quality scientific support. Bioss Inc is located in the greater Boston area of Massachusetts, the center of the world's largest and fastest growing biotech community.