c-Kit(Tyr721) Polyclonal Antibody | Bioss bs-3242R product information

product summary

company name :

Bioss

product type :

antibody

product name :

c-Kit(Tyr721) Polyclonal Antibody

catalog :

bs-3242R

quantity :

100 ul

price :

309.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; dog	Halsey C, Thamm D, Weishaar K, Burton J, Charles J, Gustafson D, et al. Expression of Phosphorylated KIT in Canine Mast Cell Tumor. Vet Pathol. 2017;:300985816688943 pubmed publisher

product information

sku :

bs-3242R

name :

c-Kit(Tyr721) Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

c-Kit Tyr721

specificity :

This phosphorylation site is homologous to that of Tyr723 in Mouse and Tyr722 in Rat.

modification :

Phosphorylation

modification site :

Tyr721

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

700-750/976

subcellular locations :

Cytoplasm

source :

KLH conjugated synthetic phosphopeptide derived from human c-Kit around the phosphorylation site of Tyr721

gene id link :

Entrez Gene: 3815

swiss prot :

P10721

swiss prot link :

Swiss Prot: P10721

applications :

WB, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

309.5 USD

background :

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

PBT; SCFR; C-Kit; CD117; Mast/stem cell growth factor receptor Kit; Piebald trait protein; Proto-oncogene c-Kit; Tyrosine-protein kinase Kit; p145 c-kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; KIT

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage