product summary
Loading...
company name :
Bioss
product type :
antibody
product name :
ASK1 (Thr845) Polyclonal Antibody
catalog :
bs-3031R
quantity :
100 ul
price :
309.5 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
citations: 1
product information
sku :
bs-3031R
name :
ASK1 (Thr845) Polyclonal Antibody
category :
Primary Antibody
conjugation :
Unconjugated
host :
Rabbit
target protein :
ASK1 Thr845
modification :
Phosphorylation
modification site :
Thr845
clonality :
Polyclonal
isotype :
IgG
concentration :
1ug/ul
public immunogen range :
825-875/1380
subcellular locations :
Cytoplasm
source :
KLH conjugated synthetic phosphopeptide derived from mouse ASK1 around the phosphorylation site of Thr845
gene id link :
Entrez Gene: 26408
swiss prot :
O35099
swiss prot link :
Swiss Prot: O35099
applications :
WB, IHC-P, IF(IHC-P)
applications with dilutions :
WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
cross reactive species :
Human, Mouse
size :
100 ul
price :
309.5 USD
background :
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response, which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals, such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1, MAP2K3/MKK3, MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
purification :
Purified by Protein A.
storage :
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
synonyms :
ASK; ASK1; Mekk5; MAPKKK5; 742452D2Rik; Mitogen-activated protein kinase kinase kinase 5; Apoptosis signal-regulating kinase 1; ASK-1; MAPK/ERK kinase kinase 5; MEK kinase 5; MEKK 5; Map3k5
lead time :
3 to 5 business days.
more info or order :
company information
Bioss
500 West Cummings Park
Suite 6500
Woburn, MA 01801
Suite 6500
Woburn, MA 01801
info@biossusa.com
biossusa.com800-501-7654
headquarters: USA
Bioss Inc is a leading antibody developer and manufacturer with state of the art technologies. We have developed over 11,000 antigens/primary antibodies and more than 130,000 derived products including fluorochrome conjugated antibodies. In addition to reliable loading control and tag antibodies, our catalog includes over 1000 specific antibodies recognizing proteins with phosphorylation, acetylation, or methylation modifications. Our company promises fast delivery with strong, top quality scientific support. Bioss Inc is located in the greater Boston area of Massachusetts, the center of the world's largest and fastest growing biotech community.