ERK1/2(Thr202 + Tyr204) Antibody | Bioss bs-3016R product information

product summary

company name :

Bioss

product type :

antibody

product name :

ERK1/2(Thr202 + Tyr204) Antibody

catalog :

bs-3016R

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs, bovine

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 4c, 4h	Qin X, Li J, Wang S, Lv J, Luan F, Liu Y, et al. Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer. Theranostics. 2021;11:6950-6965 pubmed publisher
western blot; rat; 1:1000; loading ...; fig 6a	Lu C, Yang W, Zhou J, Zhang Z, Gong Y, Hu F, et al. Inhibition of Pre-B Cell Colony Enhancing Factor Reduces Lung Injury in Rats Receiving Cardiopulmonary Bypass. Drug Des Devel Ther. 2021;15:51-60 pubmed publisher
western blot; rat	Liu L, Huang W, Wang J, Song H, Cen J, Ji B. Anthraquinone derivative exerted hormetic effect on the apoptosis in oxygen-glucose deprivation-induced PC12 cells via ERK and Akt activated Nrf2/HO-1 signaling pathway. Chem Biol Interact. 2017;262:1-11 pubmed publisher
western blot; dogs	Liu C, Jiang X, Zhang J, Li B, Li J, Xie D, et al. Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system. BMC Cardiovasc Disord. 2016;16:192 pubmed
immunohistochemistry - paraffin section; rat	Wang X, Chen Y, Tang X, Jiang L, Ji P. AMD3100 Attenuates Matrix Metalloprotease-3 and -9 Expressions and Prevents Cartilage Degradation in a Monosodium Iodo-Acetate-Induced Rat Model of Temporomandibular Osteoarthritis. J Oral Maxillofac Surg. 2016;74:927.e1-927.e13 pubmed publisher
western blot; mouse	Chen W, Bao Y, Chen X, Burton J, Gong X, Gu D, et al. Mycobacterium tuberculosis PE25/PPE41 protein complex induces activation and maturation of dendritic cells and drives Th2-biased immune responses. Med Microbiol Immunol. 2016;205:119-31 pubmed publisher
western blot; mouse	Geng S, Zhu W, Xie C, Li X, Wu J, Liang Z, et al. Medium-chain triglyceride ameliorates insulin resistance and inflammation in high fat diet-induced obese mice. Eur J Nutr. 2016;55:931-40 pubmed publisher

product information

sku :

bs-3016R

name :

ERK1/2(Thr202 + Tyr204) Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

ERK1/2 Thr202 + Tyr204

modification :

Phosphorylation

modification site :

Thr202 + Tyr204

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

196-210/379

subcellular locations :

Cytoplasm, Nucleus

source :

KLH conjugated synthetic phosphopeptide derived from human p44/42 MAPK around the phosphorylation site of (Thr202/Tyr204)

gene id link :

Entrez Gene: 5595

swiss prot :

P27361

swiss prot link :

Swiss Prot: P27361

applications :

WB, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat, Bovine

size :

100 ul

background :

p44/42 MAP Kinase(Thr202); ERK (extracellular signal regulated kinase), also known as MAPK (mitogen activated protein kinase) has two closely related isoforms of 44 kDa and 42 kDa, respectively. These kinases belong to a family of serine/threonine kinases that are activated upon treatment of cells with a large variety of stimuli including mitogens, hormones, growth factors, cytokines, and bioactive peptides. Cell stimulation induces the activation of a signaling cascade, the downstream effects of which have been linked to the regulation of cell growth and differentiation as well as the cytoskeleton. ERK1 and ERK2 are phosphorylated within the activation loop on both a Threonine and a Tyrosine residue (within a Thr-Glu-Tyr motif) by MEKs (MAPK/ERK kinases), thereby greatly elevating the activity of ERK1&2.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

ERK1; ERT2; ERK-1; PRKM3; P44ERK1; P44MAPK; HS44KDAP; HUMKER1A; p44-ERK1; p44-MAPK; Mitogen-activated protein kinase 3; MAP kinase 3; MAPK 3; Extracellular signal-regulated kinase 1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; Microtubule-associated protein 2 kinase; MAPK3

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage