GPNMB Polyclonal Antibody | Bioss bs-2684R product information

product summary

company name :

Bioss

product type :

antibody

product name :

GPNMB Polyclonal Antibody

catalog :

bs-2684R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
western blot; rat	Frara N, Abdelmagid S, Tytell M, Amin M, Popoff S, Safadi F, et al. Growth and repair factors, osteoactivin, matrix metalloproteinase and heat shock protein 72, increase with resolution of inflammation in musculotendinous tissues in a rat model of repetitive grasping. BMC Musculoskelet Disord. 2016;17:34 pubmed publisher
western blot; human	Arosarena O, DeLa Cadena R, Denny M, Bryant E, Barr E, Thorpe R, et al. Osteoactivin Promotes Migration of Oral Squamous Cell Carcinomas. J Cell Physiol. 2016;231:1761-70 pubmed publisher
western blot; mouse	Abdelmagid S, Sondag G, Moussa F, Belcher J, Yu B, Stinnett H, et al. Mutation in Osteoactivin Promotes Receptor Activator of NFÎºB Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast Function. J Biol Chem. 2015;290:20128-46 pubmed publisher
immunohistochemistry - paraffin section; human	Ruan W, Li Y, Nie G, Zhou W, Zou X. Differential expression of glycoprotein non-metastatic melanoma protein B (GPNMB) involved in trichostatin A-induced apoptosis in gastric cancer. Int J Clin Exp Med. 2014;7:4857-66 pubmed
	Neal M, Boyle A, Budge K, Safadi F, Richardson J. The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor. J Neuroinflammation. 2018;15:73 pubmed publisher
	Oyewumi M, Manickavasagam D, Novak K, Wehrung D, Paulic N, Moussa F, et al. Osteoactivin (GPNMB) ectodomain protein promotes growth and invasive behavior of human lung cancer cells. Oncotarget. 2016;7:13932-44 pubmed publisher

product information

sku :

bs-2684R

name :

GPNMB Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

GPNMB

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

85-135/572

subcellular locations :

Extracellular

source :

KLH conjugated synthetic peptide derived from human GPNMB

gene id link :

Entrez Gene: 10457

swiss prot :

Q14956

swiss prot link :

Swiss Prot: Q14956

applications :

WB, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

NMB; HGFIN; Transmembrane glycoprotein NMB; Transmembrane glycoprotein HGFIN; GPNMB; UNQ1725/PRO9925

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage