product summary
company name :
Bioss
product type :
antibody
product name :
Polycystin 1 Polyclonal Antibody
catalog :
bs-2157R
quantity :
100 ul
price :
289.5 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Bioss product webpage
citations: 5
Published Application/Species/Sample/DilutionReference
  • western blot; mouse
Kito Y, Saigo C, Takeuchi T. Novel Transgenic Mouse Model of Polycystic Kidney Disease. Am J Pathol. 2017;187:1916-1922 pubmed publisher
  • immunohistochemistry - paraffin section; human
Ren J, Xia H, Yang J, Zhu J, Zhang W, Chen G, et al. Down-regulation of polycystin in lymphatic malformations: possible role in the proliferation of lymphatic endothelial cells. Hum Pathol. 2017;65:231-238 pubmed publisher
  • immunohistochemistry - frozen section; mouse
Ohata S, Herranz Pérez V, Nakatani J, Boletta A, García Verdugo J, Álvarez Buylla A. Mechanosensory Genes Pkd1 and Pkd2 Contribute to the Planar Polarization of Brain Ventricular Epithelium. J Neurosci. 2015;35:11153-68 pubmed publisher
  • immunoprecipitation; mouse
Chiou Y, Sang S, Cheng K, Ho C, Wang Y, Pan M. Peracetylated (-)-epigallocatechin-3-gallate (AcEGCG) potently prevents skin carcinogenesis by suppressing the PKD1-dependent signaling pathway in CD34+ skin stem cells and skin tumors. Carcinogenesis. 2013;34:1315-22 pubmed publisher
Winokurow N, Schumacher S. A role for polycystin-1 and polycystin-2 in neural progenitor cell differentiation. Cell Mol Life Sci. 2019;76:2851-2869 pubmed publisher
product information
sku :
bs-2157R
name :
Polycystin 1 Polyclonal Antibody
category :
Primary Antibody
conjugation :
Unconjugated
host :
Rabbit
target protein :
Polycystin 1
modification :
Unmodified
clonality :
Polyclonal
isotype :
IgG
concentration :
1ug/ul
public immunogen range :
131-180/4303
subcellular locations :
Extracellular
source :
KLH conjugated synthetic peptide derived from human Polycystin 1
gene id link :
Entrez Gene: 5310
swiss prot :
P98161
swiss prot link :
Swiss Prot: P98161
applications :
IHC-P, IF(IHC-P)
applications with dilutions :
IHC-P(1:100-500), IF(IHC-P)(1:50-200)
cross reactive species :
Human, Mouse
size :
100 ul
price :
289.5 USD
background :
Involved in renal tubulogenesis. Involved in fluid-flow mechanosensation by the primary cilium in renal epithelium. Acts as a regulator of cilium length, together with PKD2. The dynamic control of cilium length is essential in the regulation of mechanotransductive signaling. The cilium length response creates a negative feedback loop whereby fluid shear-mediated deflection of the primary cilium, which decreases intracellular cAMP, leads to cilium shortening and thus decreases flow-induced signaling (By similarity). May be an ion-channel regulator. Involved in adhesive protein-protein and protein-carbohydrate interactions.
purification :
Purified by Protein A.
storage :
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
synonyms :
PBP; Pc-1; TRPP1; Polycystin-1; Autosomal dominant polycystic kidney disease 1 protein; PKD1
lead time :
3 to 5 business days.
more info or order :
Bioss product webpage
company information
Bioss
500 West Cummings Park
Suite 6500
Woburn, MA 01801
info@biossusa.com
http://biossusa.com
800-501-7654
headquarters: USA
Bioss Inc is a leading antibody developer and manufacturer with state of the art technologies. We have developed over 11,000 antigens/primary antibodies and more than 130,000 derived products including fluorochrome conjugated antibodies. In addition to reliable loading control and tag antibodies, our catalog includes over 1000 specific antibodies recognizing proteins with phosphorylation, acetylation, or methylation modifications. Our company promises fast delivery with strong, top quality scientific support. Bioss Inc is located in the greater Boston area of Massachusetts, the center of the world's largest and fastest growing biotech community.