LOX 1 Polyclonal Antibody | Bioss bs-2044R product information

product summary

company name :

Bioss

product type :

antibody

product name :

LOX 1 Polyclonal Antibody

catalog :

bs-2044R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, rabbit

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Bioss product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse	Shibata M, Shibata E, Maemura K, Kondo Y, Harada-Shiba M. Pathological and molecular analyses of atherosclerotic lesions in ApoE-knockout mice.. Med Mol Morphol. 2017;50:130-144 pubmed publisher
western blot; mouse	Gao X, Zhao G, Li C, Lin J, Jiang N, Wang Q, et al. LOX-1 and TLR4 affect each other and regulate the generation of ROS in A. fumigatus keratitis. Int Immunopharmacol. 2016;40:392-399 pubmed publisher
western blot; rat	Deng Z, Hu M, Xin Y, Gang C. Resveratrol alleviates vascular inflammatory injury by inhibiting inflammasome activation in rats with hypercholesterolemia and vitamin D2 treatment. Inflamm Res. 2015;64:321-32 pubmed publisher
immunohistochemistry - frozen section; rat	Li C, Zhao G, Che C, Lin J, Li N, Hu L, et al. The Role of LOX-1 in Innate Immunity to Aspergillus fumigatus in Corneal Epithelial Cells.. Invest Ophthalmol Vis Sci. 2015;56:3593-603 pubmed publisher
western blot; human	Wu C, Tang Z, Jiang L, Li X, Jiang Z, Liu L. PCSK9 siRNA inhibits HUVEC apoptosis induced by ox-LDL via Bcl/Bax-caspase9-caspase3 pathway. Mol Cell Biochem. 2012;359:347-58 pubmed publisher

product information

sku :

bs-2044R

name :

LOX 1 Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

LOX 1

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

224-274/274

subcellular locations :

Extracellular

source :

KLH conjugated synthetic peptide derived from Rabbit LOX-1

gene id link :

Entrez Gene: 100009322

swiss prot :

Q9XTA8

swiss prot link :

Swiss Prot: Q9XTA8

applications :

WB, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria (By similarity).

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

LOX1; LOX-1; Oxidized low-density lipoprotein receptor 1; Ox-LDL receptor 1; Lectin-like oxidized LDL receptor 1; Lectin-like oxLDL receptor 1; Lectin-type oxidized LDL receptor 1; OLR1

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage