Nrf2 (Ser40) Polyclonal Antibody | Bioss bs-2013R product information

product summary

company name :

Bioss

product type :

antibody

product name :

Nrf2 (Ser40) Polyclonal Antibody

catalog :

bs-2013R

quantity :

100 ul

price :

309.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Bioss product webpage

citations: 17

Published Application/Species/Sample/Dilution	Reference
western blot; mouse	Ghosh A, Abdo S, Zhao S, Wu C, Shi Y, Lo C, et al. Insulin Inhibits Nrf2 Gene Expression via Heterogeneous Nuclear Ribonucleoprotein F/K in Diabetic Mice.. Endocrinology. 2017;158:903-919 pubmed publisher
western blot; mouse	Yen T, Chen R, Jayakumar T, Lu W, Hsieh C, Hsu M, et al. Andrographolide stimulates p38 mitogen-activated protein kinase-nuclear factor erythroid-2-related factor 2-heme oxygenase 1 signaling in primary cerebral endothelial cells for definite protection against ischemic stroke in rats. Transl Res. 2016;170:57-72 pubmed publisher
western blot; mouse	Allard J, Perez E, Fukui K, Carpenter P, Ingram D, De Cabo R. Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice. Behav Brain Res. 2016;301:1-9 pubmed publisher
immunocytochemistry; mouse	Ko S, Rho D, Jeon J, Kim Y, Woo H, Lee Y, et al. Bacteroides fragilis Enterotoxin Upregulates Heme Oxygenase-1 in Intestinal Epithelial Cells via a Mitogen-Activated Protein Kinase- and NF-κB-Dependent Pathway, Leading to Modulation of Apoptosis. Infect Immun. 2016;84:2541-54 pubmed publisher
western blot; rat	Kim M, Kim E, Jung H, Yang D, Park E, Jun H. EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage. Toxicol Appl Pharmacol. 2016;315:60-69 pubmed publisher
immunohistochemistry - paraffin section; rat	Chang W, Wu S, Xu K, Liao B, Wu J, Cheng A. Scopoletin protects against methylglyoxal-induced hyperglycemia and insulin resistance mediated by suppression of advanced glycation endproducts (AGEs) generation and anti-glycation. Molecules. 2015;20:2786-801 pubmed publisher
western blot; rat	Kaneko Y, Takayanagi T, Nagasaki H, Kodani Y, Nakashima A, Mori K, et al. Aripiprazole increases NAD(P)H-quinone oxidoreductase-1 and heme oxygenase-1 in PC12 cells. J Neural Transm (Vienna). 2015;122:757-72 pubmed publisher
flow cytometry; mouse	Patwardhan R, Sharma D, Checker R, Sandur S. Mitigation of radiation-induced hematopoietic injury via regulation of cellular MAPK/phosphatase levels and increasing hematopoietic stem cells. Free Radic Biol Med. 2014;68:52-64 pubmed publisher
western blot; rat	Lee B, Hsu W, Chang Y, Kuo H, Hsu Y, Pan T. Ankaflavin: a natural novel PPARγ agonist upregulates Nrf2 to attenuate methylglyoxal-induced diabetes in vivo. Free Radic Biol Med. 2012;53:2008-16 pubmed publisher
immunohistochemistry - paraffin section; rat	Kakehashi A, Kato A, Ishii N, Wei M, Morimura K, Fukushima S, et al. Valerian inhibits rat hepatocarcinogenesis by activating GABA(A) receptor-mediated signaling. PLoS ONE. 2014;9:e113610 pubmed publisher
western blot; mouse western blot; human	Lee B, Hsu W, Hsu Y, Pan T. Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid. Free Radic Biol Med. 2013;60:7-16 pubmed publisher
western blot; mouse	Lee B, Lee C, Cheng Y, Chang W, Hsu W, Wu S. Graptopetalum paraguayense and resveratrol ameliorates carboxymethyllysine (CML)-induced pancreas dysfunction and hyperglycemia. Food Chem Toxicol. 2013;62:492-8 pubmed publisher
	Ko S, Rho D, Jeon J, Kim Y, Woo H, Kim N, et al. Crude Preparations of Helicobacter pylori Outer Membrane Vesicles Induce Upregulation of Heme Oxygenase-1 via Activating Akt-Nrf2 and mTOR-IκB Kinase-NF-κB Pathways in Dendritic Cells. Infect Immun. 2016;84:2162-74 pubmed publisher
	Santofimia-Castaño P, Clea Ruy D, García-Sanchez L, Jimenez-Blasco D, Fernández-Bermejo M, Bolanos J, et al. Melatonin induces the expression of Nrf2-regulated antioxidant enzymes via PKC and Ca2+ influx activation in mouse pancreatic acinar cells. Free Radic Biol Med. 2015;87:226-36 pubmed publisher
	Hsu W, Lee B, Li C, Hsu Y, Pan T. Monascin and AITC attenuate methylglyoxal-induced PPARγ phosphorylation and degradation through inhibition of the oxidative stress/PKC pathway depending on Nrf2 activation. J Agric Food Chem. 2013;61:5996-6006 pubmed publisher
	Mo C, Wang L, Zhang J, Numazawa S, Tang H, Tang X, et al. The crosstalk between Nrf2 and AMPK signal pathways is important for the anti-inflammatory effect of berberine in LPS-stimulated macrophages and endotoxin-shocked mice. Antioxid Redox Signal. 2014;20:574-88 pubmed publisher
	Li Y, Guo Y, Xi M, Yang P, Zhou X, Yin S, et al. Saponins from Aralia taibaiensis attenuate D-galactose-induced aging in rats by activating FOXO3a and Nrf2 pathways. Oxid Med Cell Longev. 2014;2014:320513 pubmed publisher

product information

sku :

bs-2013R

name :

Nrf2 (Ser40) Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

Nrf2 Ser40

modification :

Phosphorylation

modification site :

Ser40

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

15-65/605

source :

KLH conjugated synthetic phosphopeptide derived from human Nrf2 around the phosphorylation site of Ser40 [DF(p-S)QR]

gene id link :

Entrez Gene: 4780

swiss prot :

Q16236

swiss prot link :

Swiss Prot: Q16236

applications :

WB, IHC-P, IHC-F, IF(IHC-P), IF(IHC-F)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IHC-F(1:100-500), IF(IHC-P)(1:50-200), IF(IHC-F)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

309.5 USD

background :

Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

NRF2; Nuclear factor erythroid 2-related factor 2; NF-E2-related factor 2; NFE2-related factor 2; HEBP1; Nuclear factor, erythroid derived 2, like 2; NFE2L2

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage