PCNA-Proliferation Marker Antibody | Bioss bs-2006R product information

product summary

company name :

Bioss

product type :

antibody

product name :

PCNA-Proliferation Marker Antibody

catalog :

bs-2006R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, sheep

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; mouse	Ji W, Liu S, Zhao X, Guo Y, Xia S, Lu Y, et al. Triptolide inhibits proliferation, differentiation and induces apoptosis of osteoblastic MC3T3‑E1 cells.. Mol Med Rep. 2017;16:7391-7397 pubmed publisher
western blot; sheep; loading ...; fig 6a	Zhao Y, Feng Y, Zhang H, Kou X, Li L, Liu X, et al. Inhibition of peripubertal sheep mammary gland development by cysteamine through reducing progesterone and growth factor production. Theriogenology. 2017;89:280-288 pubmed publisher
immunohistochemistry - paraffin section; mouse	Liang S, Peng X, Li X, Yang P, Xie L, Li Y, et al. Silencing of CXCR4 sensitizes triple-negative breast cancer cells to cisplatin. Oncotarget. 2015;6:1020-30 pubmed

product information

sku :

bs-2006R

name :

PCNA-Proliferation Marker Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

PCNA-proliferation Marker

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

209-241/261

subcellular locations :

Nucleus, Helical

source :

KLH conjugated synthetic peptide derived from human PCNA

gene id link :

Entrez Gene: 5111

swiss prot :

P12004

swiss prot link :

Swiss Prot: P12004

applications :

WB, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

ATLD2; Proliferating cell nuclear antigen; PCNA; Cyclin

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage