ATF4/CREB-2 Polyclonal Antibody | Bioss bs-1531R product information

product summary

company name :

Bioss

product type :

antibody

product name :

ATF4/CREB-2 Polyclonal Antibody

catalog :

bs-1531R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, bovine

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; bovine; 1:500; loading ...; fig 5a	Dai W, Zhao F, Liu J, Liu H. Seryl-tRNA synthetase is involved in methionine stimulation of β-casein synthesis in bovine mammary epithelial cells. Br J Nutr. 2020;123:489-498 pubmed publisher
western blot; human	Hayashi K, Ouchi M, Endou H, Anzai N. HOXB9 acts as a negative regulator of activated human T cells in response to amino acid deficiency. Immunol Cell Biol. 2016;94:612-7 pubmed publisher
western blot; human	Jiang M, Yun Q, Shi F, Niu G, Gao Y, Xie S, et al. Downregulation of miR-384-5p attenuates rotenone-induced neurotoxicity in dopaminergic SH-SY5Y cells through inhibiting endoplasmic reticulum stress. Am J Physiol Cell Physiol. 2016;310:C755-63 pubmed publisher
	Fang J, Yan Y, Teng X, Wen X, Li N, Peng S, et al. Melatonin prevents senescence of canine adipose-derived mesenchymal stem cells through activating NRF2 and inhibiting ER stress. Aging (Albany NY). 2018;10:2954-2972 pubmed publisher

product information

sku :

bs-1531R

name :

ATF4/CREB-2 Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

ATF4/CREB-2

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

240-290/351

subcellular locations :

Cytoplasm, Nucleus, Cell membrane

source :

KLH conjugated synthetic peptide derived from human ATF4

gene id link :

Entrez Gene: 468

swiss prot :

P18848

swiss prot link :

Swiss Prot: P18848

applications :

WB, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

Transcriptional activator. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production (By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase (ASNS) in response to ER stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements (CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

CREB2; TXREB; CREB-2; TAXREB67; Cyclic AMP-dependent transcription factor ATF-4; cAMP-dependent transcription factor ATF-4; Activating transcription factor 4; Cyclic AMP-responsive element-binding protein 2; cAMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; Tax-responsive enhancer element-binding protein 67; ATF4

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage