Notch1/MOTC Polyclonal Antibody | Bioss bs-1335R product information

product summary

company name :

Bioss

product type :

antibody

product name :

Notch1/MOTC Polyclonal Antibody

catalog :

bs-1335R

quantity :

100 ul

price :

279 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human	Wang S, Fan H, Xu J, Zhao E. Prognostic implication of NOTCH1 in early stage oral squamous cell cancer with occult metastases. Clin Oral Investig. 2018;22:1131-1138 pubmed publisher

product information

sku :

bs-1335R

name :

Notch1/MOTC Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

Notch1/MOTC

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

2150-2200/2555

subcellular locations :

Cytoplasm

source :

KLH conjugated synthetic peptide derived from human Notch1

gene id link :

Entrez Gene: 4851

swiss prot :

P46531

swiss prot link :

Swiss Prot: P46531

applications :

IHC-P, IF(IHC-P)

applications with dilutions :

IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

279 USD

background :

Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved in mesoderm development, somite formation and neurogenesis. May enhance HIF1A function by sequestering HIF1AN away from HIF1A. Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury. Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO).

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

hN1; AOS5; TAN1; AOVD1; Neurogenic locus notch homolog protein 1; Notch 1; Translocation-associated notch protein TAN-1; NOTCH1

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage