MyD88 Polyclonal Antibody | Bioss bs-1047R product information

product summary

company name :

Bioss

product type :

antibody

product name :

MyD88 Polyclonal Antibody

catalog :

bs-1047R

quantity :

100 ul

price :

289.5 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; mouse	Li C, Yu Y, Li W, Liu B, Jiao X, Song X, et al. Phycocyanin attenuates pulmonary fibrosis via the TLR2-MyD88-NF-?B signaling pathway. Sci Rep. 2017;7:5843 pubmed publisher
western blot; rat	Fu J, Xia X, Liu Z, Wang Y, Wang Y, Shi Q, et al. The acute exposure of tetrachloro-p-benzoquinone (a.k.a. chloranil) triggers inflammation and neurological dysfunction via Toll-like receptor 4 signaling: The protective role of melatonin preconditioning. Toxicology. 2017;381:39-50 pubmed publisher
western blot; rat; 1:500; loading ...; fig 5d	Chen G, Ye X, Zhang J, Tang T, Li L, Lu P, et al. Limb Remote Ischemic Postconditioning Reduces Ischemia-Reperfusion Injury by Inhibiting NADPH Oxidase Activation and MyD88-TRAF6-P38MAP-Kinase Pathway of Neutrophils. Int J Mol Sci. 2016;17: pubmed
immunoprecipitation; rat western blot; rat	Fu J, Shi Q, Song X, Liu Z, Wang Y, Wang Y, et al. From the Cover: Tetrachlorobenzoquinone Exerts Neurological Proinflammatory Activity by Promoting HMGB1 Release, Which Induces TLR4 Clustering within the Lipid Raft. Toxicol Sci. 2016;153:303-15 pubmed publisher
western blot; mouse	Wang D, Shi J, Lv S, Xu W, Li J, Ge W, et al. Artesunate Attenuates Lipopolysaccharide-Stimulated Proinflammatory Responses by Suppressing TLR4, MyD88 Expression, and NF-ÎºB Activation in Microglial Cells. Inflammation. 2015;38:1925-32 pubmed publisher

product information

sku :

bs-1047R

name :

MyD88 Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

MyD88

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

240-290/296

subcellular locations :

Cytoplasm

source :

KLH conjugated synthetic peptide derived from mouse MyD88

gene id link :

Entrez Gene: 17874

swiss prot :

P22366

swiss prot link :

Swiss Prot: P22366

applications :

WB, IHC-P, IF(IHC-P)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

price :

289.5 USD

background :

Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Isoform 2 is defective in its ability to induce IRAK phosphorylation and NF-kappa-B activation and can function as a negative regulator of activation by IL-1 or lipopolysaccharide (LPS). Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

Myeloid differentiation primary response protein MyD88; Myd88

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage