TLR4 Polyclonal Antibody | Bioss bs-1021R product information

product summary

company name :

Bioss

product type :

antibody

product name :

TLR4 Polyclonal Antibody

catalog :

bs-1021R

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:200; loading ...; fig 2c	Gao Y, Sun Y, Ercan Sencicek A, King J, Akerberg B, Ma Q, et al. YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes. Int J Mol Sci. 2021;22: pubmed publisher
immunohistochemistry - paraffin section; human	Harasymowicz N, Clement N, Azfer A, Burnett R, Salter D, Simpson A. Regional Differences Between Perisynovial and Infrapatellar Adipose Tissue Depots and Their Response to Class II and Class III Obesity in Patients With Osteoarthritis. Arthritis Rheumatol. 2017;69:1396-1406 pubmed publisher
western blot; mouse	Kawakita F, Fujimoto M, Liu L, Nakano F, Nakatsuka Y, Suzuki H. Effects of Toll-Like Receptor 4 Antagonists Against Cerebral Vasospasm After Experimental Subarachnoid Hemorrhage in Mice. Mol Neurobiol. 2017;54:6624-6633 pubmed publisher
immunohistochemistry - paraffin section; rat	Arfian N, Muflikhah K, Soeyono S, Sari D, Tranggono U, Anggorowati N, et al. Vitamin D Attenuates Kidney Fibrosis via Reducing Fibroblast Expansion, Inflammation, and Epithelial Cell Apoptosis. Kobe J Med Sci. 2016;62:E38-44 pubmed
immunohistochemistry - paraffin section; rat	Namisaki T, Noguchi R, Moriya K, Kitade M, Aihara Y, Douhara A, et al. Beneficial effects of combined ursodeoxycholic acid and angiotensin-II type 1 receptor blocker on hepatic fibrogenesis in a rat model of nonalcoholic steatohepatitis. J Gastroenterol. 2016;51:162-72 pubmed publisher

product information

sku :

bs-1021R

name :

TLR4 Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

TLR4

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

780-830/835

subcellular locations :

Cytoplasm

source :

KLH conjugated synthetic peptide derived from rat TLR4

gene id link :

Entrez Gene: 21898

swiss prot :

Q9QX05

swiss prot link :

Swiss Prot: Q9QX05

applications :

WB, IHC-P, IF(IHC-P), IF(ICC)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)

cross reactive species :

Human, Mouse, Rat, Bovine

size :

100 ul

background :

Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6, which is rapidly internalized and triggers inflammatory response, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

Lps; Ly87; Ran/M1; Rasl2-8; Toll-like receptor 4; CD284; Tlr4

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage