product summary
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company name :
Bioss
product type :
antibody
product name :
HPV16 E6 protein Polyclonal Antibody
catalog :
bs-0990R
quantity :
100 ul
price :
289.5 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, Human papillomavirus type 16
application :
western blot, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Bioss product webpage
citations: 2
Published Application/Species/Sample/DilutionReference
  • western blot; human
Shao J, Sun J, Wang S, Chung K, Du J, Wang J, et al. HPV16 E6/E7 upregulates HIF-2α and VEGF by inhibiting LKB1 in lung cancer cells. Tumour Biol. 2017;39:1010428317717137 pubmed publisher
  • western blot; human
Yang J, Li X, Wang X, Hou W, Qiu X, Wang E, et al. Long-term persistent infection of HPV 16 E6 up-regulate SP1 and hTERT by inhibiting LKB1 in lung cancer cells. PLoS ONE. 2017;12:e0182775 pubmed publisher
product information
sku :
bs-0990R
name :
HPV16 E6 protein Polyclonal Antibody
category :
Primary Antibody
conjugation :
Unconjugated
host :
Rabbit
target protein :
HPV16 E6 protein
modification :
Unmodified
clonality :
Polyclonal
isotype :
IgG
concentration :
1ug/ul
public immunogen range :
100-150/158
subcellular locations :
Nucleus
source :
synthetic peptide from HPV16-E6 conjugated to KLH
gene id link :
Entrez Gene: 1489078
swiss prot :
P03126
swiss prot link :
Swiss Prot: P03126
applications :
IHC-P, IF(IHC-P)
applications with dilutions :
IHC-P(1:100-500), IF(IHC-P)(1:50-200)
cross reactive species :
Virus
cross reactive species details :
HPV16
size :
100 ul
price :
289.5 USD
background :
Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including Bak, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.
purification :
Purified by Protein A.
storage :
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
synonyms :
E6; HPV16 E6 protein; Human Papilloma Virus; Human papillomavirus type 16 E6; Human papillomavirus type 16; Protein E6; E6 protein; HPV16 E6; HPV16-E6; VE6_HPV16.
lead time :
3 to 5 business days.
more info or order :
Bioss product webpage
company information
Bioss
500 West Cummings Park
Suite 6500
Woburn, MA 01801
info@biossusa.com
biossusa.com
800-501-7654
headquarters: USA
Bioss Inc is a leading antibody developer and manufacturer with state of the art technologies. We have developed over 11,000 antigens/primary antibodies and more than 130,000 derived products including fluorochrome conjugated antibodies. In addition to reliable loading control and tag antibodies, our catalog includes over 1000 specific antibodies recognizing proteins with phosphorylation, acetylation, or methylation modifications. Our company promises fast delivery with strong, top quality scientific support. Bioss Inc is located in the greater Boston area of Massachusetts, the center of the world's largest and fastest growing biotech community.