product summary
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company name :
Bioss
product type :
antibody
product name :
AKT1/2/3 (Ser472/Ser473/Ser474) Antibody
catalog :
bs-0876R
quantity :
100 ul
price :
309.5 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Bioss product webpage
citations: 2
Published Application/Species/Sample/DilutionReference
  • western blot; rat; 1:500; fig 5
Li G, Jia J, Ji K, Gong X, Wang R, Zhang X, et al. The neutrophil elastase inhibitor, sivelestat, attenuates sepsis-related kidney injury in rats. Int J Mol Med. 2016;38:767-75 pubmed publisher
  • western blot; human; 1:10,000; loading ...; fig 4c
Santos J, Mesquita D, Barros-Silva J, Jeronimo C, Henrique R, Morais A, et al. Uncovering potential downstream targets of oncogenic GRPR overexpression in prostate carcinomas harboring ETS rearrangements. Oncoscience. 2015;2:497-507 pubmed
product information
sku :
bs-0876R
name :
AKT1/2/3 (Ser472/Ser473/Ser474) Antibody
category :
Primary Antibody
conjugation :
Unconjugated
host :
Rabbit
target protein :
AKT1/2/3 (Ser472/Ser473/Ser474)
modification :
Phosphorylation
modification site :
Ser473
clonality :
Polyclonal
isotype :
IgG
concentration :
1ug/ul
public immunogen range :
450-480/480
subcellular locations :
Cytoplasm, Nucleus
source :
KLH conjugated synthetic phosphopeptide derived from human AKT1 around the phosphorylation site of Ser473
gene id link :
Entrez Gene: 24185
swiss prot :
P47196
swiss prot link :
Swiss Prot: P47196
applications :
WB, IHC-P, IF(IHC-P)
applications with dilutions :
WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
cross reactive species :
Human, Mouse, Rat
size :
100 ul
price :
309.5 USD
background :
AKT1-specific substrates have been recently identified, including palladin (PALLD), which phosphorylation modulates cytoskeletal organization and cell motility; prohibitin (PHB), playing an important role in cell metabolism and proliferation; and CDKN1A, for which phosphorylation at 'Thr-145' induces its release from CDK2 and cytoplasmic relocalization. These recent findings indicate that the AKT1 isoform has a more specific role in cell motility and proliferation. Phosphorylates CLK2 thereby controlling cell survival to ionizing radiation.
purification :
Purified by Protein A.
storage :
Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
synonyms :
Akt; RAC-alpha serine/threonine-protein kinase; Protein kinase B; PKB; Protein kinase B alpha; PKB alpha; RAC-PK-alpha; Akt1
lead time :
3 to 5 business days.
more info or order :
Bioss product webpage
company information
Bioss
500 West Cummings Park
Suite 6500
Woburn, MA 01801
info@biossusa.com
biossusa.com
800-501-7654
headquarters: USA
Bioss Inc is a leading antibody developer and manufacturer with state of the art technologies. We have developed over 11,000 antigens/primary antibodies and more than 130,000 derived products including fluorochrome conjugated antibodies. In addition to reliable loading control and tag antibodies, our catalog includes over 1000 specific antibodies recognizing proteins with phosphorylation, acetylation, or methylation modifications. Our company promises fast delivery with strong, top quality scientific support. Bioss Inc is located in the greater Boston area of Massachusetts, the center of the world's largest and fastest growing biotech community.