HIF-1 Alpha Polyclonal Antibody | Bioss bs-0737R product information

product summary

company name :

Bioss

product type :

antibody

product name :

HIF-1 Alpha Polyclonal Antibody

catalog :

bs-0737R

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Bioss product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; loading ...; fig 6c	Shao R, Zhang Z, Xu Z, Ouyang H, Wang L, Ouyang H, et al. H3K36 methyltransferase NSD1 regulates chondrocyte differentiation for skeletal development and fracture repair. Bone Res. 2021;9:30 pubmed publisher
western blot; rat	Yang J, Lu Y, Guo A. Platelet-rich plasma protects rat chondrocytes from interleukin-1?-induced apoptosis. Mol Med Rep. 2016;14:4075-4082 pubmed publisher
immunohistochemistry - paraffin section; mouse	Madka V, Mohammed A, Li Q, Zhang Y, Biddick L, Patlolla J, et al. Targeting mTOR and p53 Signaling Inhibits Muscle Invasive Bladder Cancer In Vivo. Cancer Prev Res (Phila). 2016;9:53-62 pubmed publisher
	Talwar H, Bauerfeld C, Bouhamdan M, Farshi P, Liu Y, Samavati L. MKP-1 negatively regulates LPS-mediated IL-1β production through p38 activation and HIF-1α expression. Cell Signal. 2017;34:1-10 pubmed publisher

product information

sku :

bs-0737R

name :

HIF-1 Alpha Polyclonal Antibody

category :

Primary Antibody

conjugation :

Unconjugated

host :

Rabbit

target protein :

HIF-1 Alpha

modification :

Unmodified

clonality :

Polyclonal

isotype :

IgG

concentration :

1ug/ul

public immunogen range :

351-400/826

subcellular locations :

Cytoplasm, Nucleus

source :

KLH conjugated synthetic peptide derived from human of human HIF-1 Alpha

gene id link :

Entrez Gene: 3091

swiss prot :

Q16665

swiss prot link :

Swiss Prot: Q16665

applications :

WB, IHC-P, IF(IHC-P), IF(ICC)

applications with dilutions :

WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200), IF(ICC)(1:50-200)

cross reactive species :

Human, Mouse, Rat

size :

100 ul

background :

Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 4 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP3. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.

purification :

Purified by Protein A.

storage :

Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.

synonyms :

HIF1; MOP1; PASD8; HIF-1A; bHLHe78; HIF-1alpha; HIF1-ALPHA; Hypoxia-inducible factor 1-alpha; HIF-1-alpha; ARNT-interacting protein; Basic-helix-loop-helix-PAS protein MOP1; Class E basic helix-loop-helix protein 78; Member of PAS protein 1; PAS domain-containing protein 8; HIF1A

lead time :

3 to 5 business days.

more info or order :

Bioss product webpage